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Target
5-hydroxytryptamine receptor 1B
Ligand
BDBM50064784
Substrate
n/a
Meas. Tech.
ChEMBL_1585 (CHEMBL616996)
Ki
3023±n/a nM
Citation
 Ennis, MD; Ghazal, NB; Hoffman, RL; Smith, MW; Schlachter, SK; Lawson, CF; Im, WB; Pregenzer, JF; Svensson, KA; Lewis, RA; Hall, ED; Sutter, DM; Harris, LT; McCall, RB Isochroman-6-carboxamides as highly selective 5-HT1D agonists: potential new treatment for migraine without cardiovascular side effects. J Med Chem 41:2180-3 (1998) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 1B
Synonyms:
5-HT-1B | 5-HT1B | 5HT1B_GORGO | HTR1B | Serotonin receptor 1B
Type:
PROTEIN
Mol. Mass.:
43466.06
Organism:
Gorilla gorilla gorilla
Description:
ChEMBL_105571
Residue:
389
Sequence:
MEEPGAQCAPPPAGSETWVPQANLSSAPSQNCSAKDYIYQDSIALPWKVLLVMLLALITLATTLSNAFVIATVYRTRKLHTPANYLIASLAVTDLLVSILVMPISTMYTVTGRWTLGQVVCDFWLSSDITCCTASILHLCVIALDRYWAITDAVEYSAKRTPKRAAVMIALVWVFSISISLPPFFWRQAKAEEEVSECVVNTDHILYTVYSTVGAFYFPTLLLIALYGRIYVEARSRILKQTPNRTGKRLTRAQLITDSPGSTSSVTSINSRVPDVPSESGSPVYVNQVKVRVSDALLEKKKLMAARERKATKTLGIILGAFIVCWLPFFIISLVMPICKDACWFHLAIFDFFTWLGYLNSLINPIIYTMSNEDFKQAFHKLIRFKCTS
  
Inhibitor
Name:
BDBM50064784
Synonyms:
(S)-1-{2-[4-(4-Methoxy-phenyl)-piperazin-1-yl]-ethyl}-isochroman-6-carboxylic acid amide | CHEMBL71635
Type:
Small organic molecule
Emp. Form.:
C23H29N3O3
Mol. Mass.:
395.4947
SMILES:
COc1ccc(cc1)N1CCN(CC[C@@H]2OCCc3cc(ccc23)C(N)=O)CC1
Structure:
Search PDB for entries with ligand similarity: