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Target
Dual specificity protein phosphatase 1
Ligand
BDBM50510655
Substrate
n/a
Meas. Tech.
ChEMBL_1841934 (CHEMBL4342233)
IC50
6600±n/a nM
Citation
 Yeon Kim, B; Hee Yoon, J; Kim, M; Nyoung Kim, J; Park, H; Eon Ryu, S; Lee, S Synthesis and biological evaluation of acylthiourea against DUSP1 inhibition. Bioorg Med Chem Lett 29:1746-1748 (2019) [PubMed]  Article 
Target
Name:
Dual specificity protein phosphatase 1
Synonyms:
CL100 | DUS1_HUMAN | DUSP1 | Dual specificity protein phosphatase hVH1 | MAP kinase phosphatase 1 | MKP-1 | MKP1 | PTPN10 | Protein-tyrosine phosphatase CL100 | VH1
Type:
Protein phosphatase
Mol. Mass.:
39301.48
Organism:
Homo sapiens (Human)
Description:
gi_4758204
Residue:
367
Sequence:
MVMEVGTLDAGGLRALLGERAAQCLLLDCRSFFAFNAGHIAGSVNVRFSTIVRRRAKGAMGLEHIVPNAELRGRLLAGAYHAVVLLDERSAALDGAKRDGTLALAAGALCREARAAQVFFLKGGYEAFSASCPELCSKQSTPMGLSLPLSTSVPDSAESGCSSCSTPLYDQGGPVEILPFLYLGSAYHASRKDMLDALGITALINVSANCPNHFEGHYQYKSIPVEDNHKADISSWFNEAIDFIDSIKNAGGRVFVHCQAGISRSATICLAYLMRTNRVKLDEAFEFVKQRRSIISPNFSFMGQLLQFESQVLAPHCSAEAGSPAMAVLDRGTSTTTVFNFPVSIPVHSTNSALSYLQSPITTSPSC
  
Inhibitor
Name:
BDBM50510655
Synonyms:
CHEMBL4579674
Type:
Small organic molecule
Emp. Form.:
C23H19N3O2S
Mol. Mass.:
401.481
SMILES:
Cc1ccc(cc1)C(=O)NC(=S)Nc1cccc(c1)-c1nc2cc(C)ccc2o1
Structure:
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