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Target
Beta-secretase 1
Ligand
BDBM116257
Substrate
n/a
Meas. Tech.
ChEMBL_1842192 (CHEMBL4342619)
IC50
3.0±n/a nM
Citation
 Hsiao, CC; Rombouts, F; Gijsen, HJM New evolutions in the BACE1 inhibitor field from 2014 to 2018. Bioorg Med Chem Lett 29:761-777 (2019) [PubMed]  Article 
Target
Name:
Beta-secretase 1
Synonyms:
n/a
Type:
PROTEIN
Mol. Mass.:
55743.07
Organism:
Cricetulus griseus
Description:
ChEMBL_108394
Residue:
501
Sequence:
MAPALRWLLLWVGSGMLPAQGTHLGIRLPLRSGPAGPPLGLRLPRETDEESEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIARPDDSLEPFFDSLVKQTHIANVFSLQLCGAGFPLNQTEALASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTPDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWRCLRCLRHQHDDFADDISLLK
  
Inhibitor
Name:
BDBM116257
Synonyms:
US10035794, Example 34 | US10683287, Example 34 | US8637508, 34
Type:
Small organic molecule
Emp. Form.:
C19H15ClF7N5O2
Mol. Mass.:
513.797
SMILES:
C[C@]1(CO[C@](C)(C(N)=N1)C(F)(F)F)c1nc(NC(=O)c2ncc(cc2Cl)C(F)(F)F)ccc1F |r,c:7|
Structure:
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