Target
Estradiol 17-beta-dehydrogenase 2
Ligand
BDBM50515435
Substrate
n/a
Meas. Tech.
ChEMBL_1861111 (CHEMBL4361967)
IC50
9.0±n/a nM
Citation
 Abdelsamie, ASSalah, MSiebenbürger, LMerabet, AScheuer, CFrotscher, MMüller, STZierau, OVollmer, GMenger, MDLaschke, MWvan Koppen, CJMarchais-Oberwinkler, SHartmann, RW Design, Synthesis, and Biological Characterization of Orally Active 17?-Hydroxysteroid Dehydrogenase Type 2 Inhibitors Targeting the Prevention of Osteoporosis. J Med Chem 62:7289-7301 (2019) [PubMed]  Article 
Target
Name:
Estradiol 17-beta-dehydrogenase 2
Synonyms:
17-beta-HSD 2 | 17-beta-hydroxysteroid dehydrogenase type 2 | DHB2_RAT | Edh17b2 | Estradiol 17-beta-dehydrogenase 2 | Hsd17b2 | Testosterone 17-beta-dehydrogenase
Type:
PROTEIN
Mol. Mass.:
41973.66
Organism:
Rattus norvegicus
Description:
ChEMBL_104364
Residue:
381
Sequence:
MNPFSSESAWLCLTATAVLGGMLLCKAWSSGQLRSQVVCLAGLWGGACLLSLSLLCSLFLLSVSCFFLLYVSSSDQDLLPVDQKAVLVTGADSGFGHALAKHLDKLGFTVFAGVLDKEGPGAEELRKNCSERLSVLQMDVTKPEQIKDVHSEVAEKIQDKGLWAVVNNAGVLHFPIDGELIPMTVYRKCMAVNFFGAVEVTKVFLPLLRKSKGRLVNVSSMGAMIPFQMVAAYASTKAAISMFSAVIRQELAKWGVKVVTIHPGGFQTNIVGSQDSWDKMEKEILDHFSKEIQENYGQEYVHTQKLALPVMREMSNPDITPVLRDIQHAICAKNPSSFYCSGRMTYLWICFAAYSPISLLDYILKNYFTPKLMPRALRTAS
  
Inhibitor
Name:
BDBM50515435
Synonyms:
CHEMBL4513439
Type:
Small organic molecule
Emp. Form.:
C23H11F6NO4S2
Mol. Mass.:
543.458
SMILES:
Oc1c(F)c(F)cc(C(=O)c2ccc(s2)-c2cc(NS(=O)(=O)c3ccc(F)cc3)c(F)cc2F)c1F
Structure:
Search PDB for entries with ligand similarity: