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TargetAcetyl-coenzyme A synthetase, cytoplasmic
LigandBDBM50517059
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1867284
IC50 1.000000±n/a nM
Citation Kargbo, RB Inhibition of ACSS2 for Treatment of Cancer and Neuropsychiatric Diseases. ACS Med Chem Lett10:1100-1101 (2019) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Acetyl-coenzyme A synthetase, cytoplasmic
Name:Acetyl-coenzyme A synthetase, cytoplasmic
Synonyms:6.2.1.1 | 6.2.1.17 | ACAS2 | ACS | ACSS2 | AceCS | AceCS1 | Acetate--CoA ligase | Acetyl-CoA synthetase | Acetyl-CoA synthetase 1 | Acetyl-coenzyme A synthetase, cytoplasmic | Acyl-CoA synthetase short-chain family member 2 | Acyl-activating enzyme | Propionate--CoA ligase
Type:PROTEIN
Mol. Mass.:78577.73
Organism:Homo sapiens
Description:ChEMBL_119217
Residue:701
Sequence:
MGLPEERVRSGSGSRGQEEAGAGGRARSWSPPPEVSRSAHVPSLQRYRELHRRSVEEPRE
FWGDIAKEFYWKTPCPGPFLRYNFDVTKGKIFIEWMKGATTNICYNVLDRNVHEKKLGDK
VAFYWEGNEPGETTQITYHQLLVQVCQFSNVLRKQGIQKGDRVAIYMPMIPELVVAMLAC
ARIGALHSIVFAGFSSESLCERILDSSCSLLITTDAFYRGEKLVNLKELADEALQKCQEK
GFPVRCCIVVKHLGRAELGMGDSTSQSPPIKRSCPDVQISWNQGIDLWWHELMQEAGDEC
EPEWCDAEDPLFILYTSGSTGKPKGVVHTVGGYMLYVATTFKYVFDFHAEDVFWCTADIG
WITGHSYVTYGPLANGATSVLFEGIPTYPDVNRLWSIVDKYKVTKFYTAPTAIRLLMKFG
DEPVTKHSRASLQVLGTVGEPINPEAWLWYHRVVGAQRCPIVDTFWQTETGGHMLTPLPG
ATPMKPGSATFPFFGVAPAILNESGEELEGEAEGYLVFKQPWPGIMRTVYGNHERFETTY
FKKFPGYYVTGDGCQRDQDGYYWITGRIDDMLNVSGHLLSTAEVESALVEHEAVAEAAVV
GHPHPVKGECLYCFVTLCDGHTFSPKLTEELKKQIREKIGPIATPDYIQNAPGLPKTRSG
KIMRRVLRKIAQNDHDLGDMSTVADPSVISHLFSHRCLTIQ
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50517059
NameBDBM50517059
Synonyms:CHEMBL4535842
TypeSmall organic molecule
Emp. Form.C21H21F2N3O4
Mol. Mass.417.4059
SMILESCOc1ccc(cc1OC)N1N=C(C)C(C(=O)Nc2cccc(c2)C(C)(F)F)C1=O |t:12|
Structure
n/a