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TargetAcetyl-coenzyme A synthetase, cytoplasmic
LigandBDBM50517065
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1867284
IC50 0.330000±n/a nM
Citation Kargbo, RB Inhibition of ACSS2 for Treatment of Cancer and Neuropsychiatric Diseases. ACS Med Chem Lett10:1100-1101 (2019) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Acetyl-coenzyme A synthetase, cytoplasmic
Name:Acetyl-coenzyme A synthetase, cytoplasmic
Synonyms:6.2.1.1 | 6.2.1.17 | ACAS2 | ACS | ACSS2 | AceCS | AceCS1 | Acetate--CoA ligase | Acetyl-CoA synthetase | Acetyl-CoA synthetase 1 | Acetyl-coenzyme A synthetase, cytoplasmic | Acyl-CoA synthetase short-chain family member 2 | Acyl-activating enzyme | Propionate--CoA ligase
Type:PROTEIN
Mol. Mass.:78577.73
Organism:Homo sapiens
Description:ChEMBL_119217
Residue:701
Sequence:
MGLPEERVRSGSGSRGQEEAGAGGRARSWSPPPEVSRSAHVPSLQRYRELHRRSVEEPRE
FWGDIAKEFYWKTPCPGPFLRYNFDVTKGKIFIEWMKGATTNICYNVLDRNVHEKKLGDK
VAFYWEGNEPGETTQITYHQLLVQVCQFSNVLRKQGIQKGDRVAIYMPMIPELVVAMLAC
ARIGALHSIVFAGFSSESLCERILDSSCSLLITTDAFYRGEKLVNLKELADEALQKCQEK
GFPVRCCIVVKHLGRAELGMGDSTSQSPPIKRSCPDVQISWNQGIDLWWHELMQEAGDEC
EPEWCDAEDPLFILYTSGSTGKPKGVVHTVGGYMLYVATTFKYVFDFHAEDVFWCTADIG
WITGHSYVTYGPLANGATSVLFEGIPTYPDVNRLWSIVDKYKVTKFYTAPTAIRLLMKFG
DEPVTKHSRASLQVLGTVGEPINPEAWLWYHRVVGAQRCPIVDTFWQTETGGHMLTPLPG
ATPMKPGSATFPFFGVAPAILNESGEELEGEAEGYLVFKQPWPGIMRTVYGNHERFETTY
FKKFPGYYVTGDGCQRDQDGYYWITGRIDDMLNVSGHLLSTAEVESALVEHEAVAEAAVV
GHPHPVKGECLYCFVTLCDGHTFSPKLTEELKKQIREKIGPIATPDYIQNAPGLPKTRSG
KIMRRVLRKIAQNDHDLGDMSTVADPSVISHLFSHRCLTIQ
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50517065
NameBDBM50517065
Synonyms:CHEMBL4550594
TypeSmall organic molecule
Emp. Form.C25H20F4N4O3
Mol. Mass.500.4449
SMILESCC1=NN(C(=O)C1C(=O)Nc1cccc(c1)C(C)(F)F)c1ccc(OC(F)F)c(c1)-c1cccnc1 |t:1|
Structure
n/a