Target
Proteasome subunit beta type-10
Ligand
BDBM50517602
Substrate
n/a
Meas. Tech.
ChEMBL_1869378 (CHEMBL4370444)
IC50
200±n/a nM
Citation
 Xin, BTHuber, EMde Bruin, GHeinemeyer, WMaurits, EEspinal, CDu, YJanssens, MWeyburne, ESKisselev, AFFlorea, BIDriessen, Cvan der Marel, GAGroll, MOverkleeft, HS Structure-Based Design of Inhibitors Selective for Human Proteasome ?2c or ?2i Subunits. J Med Chem 62:1626-1642 (2019) [PubMed]  Article 
Target
Name:
Proteasome subunit beta type-10
Synonyms:
LMP10 | Low molecular mass protein 10 | MECL1 | Macropain subunit MECl-1 | Multicatalytic endopeptidase complex subunit MECl-1 | PSB10_HUMAN | PSMB10 | Proteasome MECl-1 | Proteasome subunit beta-2i
Type:
PROTEIN
Mol. Mass.:
28940.51
Organism:
Homo sapiens (Human)
Description:
ChEMBL_106197
Residue:
273
Sequence:
MLKPALEPRGGFSFENCQRNASLERVLPGLKVPHARKTGTTIAGLVFQDGVILGADTRATNDSVVADKSCEKIHFIAPKIYCCGAGVAADAEMTTRMVASKMELHALSTGREPRVATVTRILRQTLFRYQGHVGASLIVGGVDLTGPQLYGVHPHGSYSRLPFTALGSGQDAALAVLEDRFQPNMTLEAAQGLLVEAVTAGILGDLGSGGNVDACVITKTGAKLLRTLSSPTEPVKRSGRYHFVPGTTAVLTQTVKPLTLELVEETVQAMEVE
  
Inhibitor
Name:
BDBM50517602
Synonyms:
CHEMBL4435519
Type:
Small organic molecule
Emp. Form.:
C33H49N5O5S2
Mol. Mass.:
659.903
SMILES:
CC(C)C[C@H](NC(=O)c1cnc(C)s1)C(=O)N[C@@H](CC1CCC(C)CC1)C(=O)N[C@@H](Cc1ccc(CN)cc1)\C=C\S(C)(=O)=O |r,wU:17.18,wD:29.31,4.3,(43.01,-8.6,;41.68,-9.38,;41.69,-10.91,;40.35,-8.61,;40.35,-7.07,;39.02,-6.3,;37.68,-7.07,;37.68,-8.61,;36.36,-6.3,;34.95,-6.92,;33.93,-5.77,;34.7,-4.45,;34.08,-3.04,;36.2,-4.77,;41.69,-6.3,;41.69,-4.76,;43.02,-7.07,;44.35,-6.3,;44.35,-4.76,;45.69,-3.99,;47.02,-4.77,;48.35,-4.01,;48.35,-2.47,;49.69,-1.7,;47.02,-1.69,;45.68,-2.46,;45.69,-7.07,;45.69,-8.61,;47.02,-6.3,;48.35,-7.07,;48.35,-8.61,;49.69,-9.38,;49.68,-10.92,;51.01,-11.69,;52.35,-10.92,;53.68,-11.69,;55.01,-10.92,;52.34,-9.37,;51.01,-8.61,;49.69,-6.3,;51.02,-7.07,;52.35,-6.29,;53.69,-7.07,;51.57,-4.95,;53.12,-4.95,)|
Structure:
Search PDB for entries with ligand similarity: