Target
Proteasome subunit beta type-2
Ligand
BDBM50517647
Substrate
n/a
Meas. Tech.
ChEMBL_1869379 (CHEMBL4370445)
IC50
11±n/a nM
Citation
 Xin, BTHuber, EMde Bruin, GHeinemeyer, WMaurits, EEspinal, CDu, YJanssens, MWeyburne, ESKisselev, AFFlorea, BIDriessen, Cvan der Marel, GAGroll, MOverkleeft, HS Structure-Based Design of Inhibitors Selective for Human Proteasome ?2c or ?2i Subunits. J Med Chem 62:1626-1642 (2019) [PubMed]  Article 
Target
Name:
Proteasome subunit beta type-2
Synonyms:
20S proteasome | PSB2_HUMAN | PSMB2 | Proteasome Macropain subunit
Type:
PROTEIN
Mol. Mass.:
22837.53
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1294233
Residue:
201
Sequence:
MEYLIGIQGPDYVLVASDRVAASNIVQMKDDHDKMFKMSEKILLLCVGEAGDTVQFAEYIQKNVQLYKMRNGYELSPTAAANFTRRNLADCLRSRTPYHVNLLLAGYDEHEGPALYYMDYLAALAKAPFAAHGYGAFLTLSILDRYYTPTISRERAVELLRKCLEELQKRFILNLPTFSVRIIDKNGIHDLDNISFPKQGS
  
Inhibitor
Name:
BDBM50517647
Synonyms:
CHEMBL4463326
Type:
Small organic molecule
Emp. Form.:
C33H49N5O5S2
Mol. Mass.:
659.903
SMILES:
CC(C)C[C@H](NC(=O)c1cnc(C)s1)C(=O)N[C@@H](CCC1CCCCC1)C(=O)N[C@@H](Cc1ccc(CN)cc1)\C=C\S(C)(=O)=O |r|
Structure:
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