Reaction Details Report a problem with these data
Target
Acid ceramidase
Ligand
BDBM367184
Substrate
n/a
Meas. Tech.
ChEMBL_1871220 (CHEMBL4372387)
Ki
64±n/a nM
Citation
 Dementiev, A; Joachimiak, A; Nguyen, H; Gorelik, A; Illes, K; Shabani, S; Gelsomino, M; Ahn, EE; Nagar, B; Doan, N Molecular Mechanism of Inhibition of Acid Ceramidase by Carmofur. J Med Chem 62:987-992 (2019) [PubMed]  Article 
Target
Name:
Acid ceramidase
Synonyms:
ASAH | ASAH1 | ASAH1_HUMAN | Acid ceramidase | Acid ceramidase (AC)
Type:
Enzyme
Mol. Mass.:
44662.65
Organism:
Homo sapiens (Human)
Description:
Q13510
Residue:
395
Sequence:
MPGRSCVALVLLAAAVSCAVAQHAPPWTEDCRKSTYPPSGPTYRGAVPWYTINLDLPPYKRWHELMLDKAPVLKVIVNSLKNMINTFVPSGKIMQVVDEKLPGLLGNFPGPFEEEMKGIAAVTDIPLGEIISFNIFYELFTICTSIVAEDKKGHLIHGRNMDFGVFLGWNINNDTWVITEQLKPLTVNLDFQRNNKTVFKASSFAGYVGMLTGFKPGLFSLTLNERFSINGGYLGILEWILGKKDVMWIGFLTRTVLENSTSYEEAKNLLTKTKILAPAYFILGGNQSGEGCVITRDRKESLDVYELDAKQGRWYVVQTNYDRWKHPFFLDDRRTPAKMCLNRTSQENISFETMYDVLSTKPVLNKLTVYTTLIDVTKGQFETYLRDCPDPCIGW
  
Inhibitor
Name:
BDBM367184
Synonyms:
2-oxo-N-(4-phenylbutyl)-1,3- benzoxazole-3-carboxamide | US10226452, Example 1
Type:
Small organic molecule
Emp. Form.:
C18H18N2O3
Mol. Mass.:
310.3471
SMILES:
O=C(NCCCCc1ccccc1)n1c2ccccc2oc1=O
Structure:
Search PDB for entries with ligand similarity: