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Target
Beta-3 adrenergic receptor
Ligand
BDBM50073053
Substrate
n/a
Meas. Tech.
ChEMBL_38796 (CHEMBL652337)
EC50
0.06±n/a nM
Citation
 Kordik, CP; Reitz, AB Pharmacological treatment of obesity: therapeutic strategies. J Med Chem 42:181-201 (1999) [PubMed]  Article 
Target
Name:
Beta-3 adrenergic receptor
Synonyms:
ADRB3 | ADRB3R | ADRB3_HUMAN | B3AR | Beta-2 adrenergic receptor and beta-3 adrenergic receptor | Beta-3 adrenoceptor | Beta-3 adrenoreceptor | adrenergic Beta3
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
43534.88
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
408
Sequence:
MAPWPHENSSLAPWPDLPTLAPNTANTSGLPGVPWEAALAGALLALAVLATVGGNLLVIVAIAWTPRLQTMTNVFVTSLAAADLVMGLLVVPPAATLALTGHWPLGATGCELWTSVDVLCVTASIETLCALAVDRYLAVTNPLRYGALVTKRCARTAVVLVWVVSAAVSFAPIMSQWWRVGADAEAQRCHSNPRCCAFASNMPYVLLSSSVSFYLPLLVMLFVYARVFVVATRQLRLLRGELGRFPPEESPPAPSRSLAPAPVGTCAPPEGVPACGRRPARLLPLREHRALCTLGLIMGTFTLCWLPFFLANVLRALGGPSLVPGPAFLALNWLGYANSAFNPLIYCRSPDFRSAFRRLLCRCGRRLPPEPCAAARPALFPSGVPAARSSPAQPRLCQRLDGASWGVS
  
Inhibitor
Name:
BDBM50073053
Synonyms:
(2-{2-[(R)-2-(3-Chloro-phenyl)-2-hydroxy-ethylamino]-ethyl}-1H-indol-7-yloxy)-acetic acid | CHEMBL303537
Type:
Small organic molecule
Emp. Form.:
C20H21ClN2O4
Mol. Mass.:
388.845
SMILES:
O[C@@H](CNCCc1cc2cccc(OCC(O)=O)c2[nH]1)c1cccc(Cl)c1
Structure:
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