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Target
N-lysine methyltransferase SMYD2
Ligand
BDBM50519299
Substrate
n/a
Meas. Tech.
ChEMBL_1874852 (CHEMBL4376141)
IC50
6.0±n/a nM
Citation
 Taylor, AP; Swewczyk, M; Kennedy, S; Trush, VV; Wu, H; Zeng, H; Dong, A; Ferreira de Freitas, R; Tatlock, J; Kumpf, RA; Wythes, M; Casimiro-Garcia, A; Denny, RA; Parikh, MD; Li, F; Barsyte-Lovejoy, D; Schapira, M; Vedadi, M; Brown, PJ; Arrowsmith, CH; Owen, DR Selective, Small-Molecule Co-Factor Binding Site Inhibition of a Su(var)3-9, Enhancer of Zeste, Trithorax Domain Containing Lysine Methyltransferase. J Med Chem 62:7669-7683 (2019) [PubMed]  Article 
Target
Name:
N-lysine methyltransferase SMYD2
Synonyms:
HSKM-B | Histone methyltransferase SMYD2 | KMT3C | Lysine N-methyltransferase 3C | N-lysine methyltransferase SMYD2 | SET and MYND domain-containing protein 2 | SET and MYND domain-containing protein 2 (SMYD2) | SMYD2 | SMYD2_HUMAN
Type:
Enzyme
Mol. Mass.:
49689.57
Organism:
Homo sapiens (Human)
Description:
Q9NRG4
Residue:
433
Sequence:
MRAEGLGGLERFCSPGKGRGLRALQPFQVGDLLFSCPAYAYVLTVNERGNHCEYCFTRKEGLSKCGRCKQAFYCNVECQKEDWPMHKLECSPMVVFGENWNPSETVRLTARILAKQKIHPERTPSEKLLAVKEFESHLDKLDNEKKDLIQSDIAALHHFYSKHLGFPDNDSLVVLFAQVNCNGFTIEDEELSHLGSAIFPDVALMNHSCCPNVIVTYKGTLAEVRAVQEIKPGEEVFTSYIDLLYPTEDRNDRLRDSYFFTCECQECTTKDKDKAKVEIRKLSDPPKAEAIRDMVRYARNVIEEFRRAKHYKSPSELLEICELSQEKMSSVFEDSNVYMLHMMYQAMGVCLYMQDWEGALQYGQKIIKPYSKHYPLYSLNVASMWLKLGRLYMGLEHKAAGEKALKKAIAIMEVAHGKDHPYISEIKQEIESH
  
Inhibitor
Name:
BDBM50519299
Synonyms:
CHEMBL4536230
Type:
Small organic molecule
Emp. Form.:
C27H36N8O
Mol. Mass.:
488.6277
SMILES:
Cc1nc(N)c2ncn(C3CN(C3)C(=O)c3ccn(CC4CCN(CC4)C4CCCCC=C4)c3)c2n1 |c:33|
Structure:
Search PDB for entries with ligand similarity: