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TargetLeukotriene C4 synthase
LigandBDBM50519573
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1876789
IC50 16±n/a nM
Citation Munck Af Rosenschöld, MJohannesson, PNikitidis, ATyrchan, CChang, HFRönn, RChapman, DUllah, VNikitidis, GGlader, PKäck, HBonn, BWågberg, FBjörkstrand, EAndersson, USwedin, LRohman, MAndreasson, TBergström, ELJiang, FZhou, XHLundqvist, AJMalmberg, AEk, MGordon, EPettersen, ARipa, LDavis, AM Discovery of the Oral Leukotriene C4 Synthase Inhibitor (1 J Med Chem62:7769-7787 (2019) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Leukotriene C4 synthase
Name:Leukotriene C4 synthase
Synonyms:LTC4 synthase | LTC4S | Leukotriene-C(4) synthase
Type:PROTEIN
Mol. Mass.:16575.59
Organism:Homo sapiens (Human)
Description:ChEMBL_961179
Residue:150
Sequence:
MKDEVALLAAVTLLGVLLQAYFSLQVISARRAFRVSPPLTTGPPEFERVYRAQVNCSEYF
PLFLATLWVAGIFFHEGAAALCGLVYLFARLRYFQGYARSAQLRLAPLYASARALWLLVA
LAALGLLAHFLPAALRAALLGRLRTLLPWA
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50519573
NameBDBM50519573
Synonyms:CHEMBL4456770
TypeSmall organic molecule
Emp. Form.C24H22ClN3O4
Mol. Mass.451.902
SMILESCOc1nc(ncc1N(CC1CC1)c1ccc(Cl)c2ccccc12)C(=O)[C@@H]1C[C@H]1C(O)=O |r|
Structure
n/a