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TargetLeukotriene C4 synthase
LigandBDBM50519579
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1876789
IC50 5.3±n/a nM
Citation Munck Af Rosenschöld, MJohannesson, PNikitidis, ATyrchan, CChang, HFRönn, RChapman, DUllah, VNikitidis, GGlader, PKäck, HBonn, BWågberg, FBjörkstrand, EAndersson, USwedin, LRohman, MAndreasson, TBergström, ELJiang, FZhou, XHLundqvist, AJMalmberg, AEk, MGordon, EPettersen, ARipa, LDavis, AM Discovery of the Oral Leukotriene C4 Synthase Inhibitor (1 J Med Chem62:7769-7787 (2019) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Leukotriene C4 synthase
Name:Leukotriene C4 synthase
Synonyms:LTC4 synthase | LTC4S | Leukotriene-C(4) synthase
Type:PROTEIN
Mol. Mass.:16575.59
Organism:Homo sapiens (Human)
Description:ChEMBL_961179
Residue:150
Sequence:
MKDEVALLAAVTLLGVLLQAYFSLQVISARRAFRVSPPLTTGPPEFERVYRAQVNCSEYF
PLFLATLWVAGIFFHEGAAALCGLVYLFARLRYFQGYARSAQLRLAPLYASARALWLLVA
LAALGLLAHFLPAALRAALLGRLRTLLPWA
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50519579
NameBDBM50519579
Synonyms:CHEMBL4576647
TypeSmall organic molecule
Emp. Form.C21H20ClFN2O4
Mol. Mass.418.846
SMILESCOc1cc(cnc1C(=O)[C@H]1C[C@@H]1C(O)=O)N(CC1CC1)c1ccc(F)c(Cl)c1 |r|
Structure
n/a