Reaction Details Report a problem with these data
Target
WD repeat-containing protein 5
Ligand
BDBM50520121
Substrate
n/a
Meas. Tech.
ChEMBL_1879085 (CHEMBL4380479)
Ki
0.044000±n/a nM
Citation
 Tian, J; Teuscher, KB; Aho, ER; Alvarado, JR; Mills, JJ; Meyers, KM; Gogliotti, RD; Han, C; Macdonald, JD; Sai, J; Shaw, JG; Sensintaffar, JL; Zhao, B; Rietz, TA; Thomas, LR; Payne, WG; Moore, WJ; Stott, GM; Kondo, J; Inoue, M; Coffey, RJ; Tansey, WP; Stauffer, SR; Lee, T; Fesik, SW Discovery and Structure-Based Optimization of Potent and Selective WD Repeat Domain 5 (WDR5) Inhibitors Containing a Dihydroisoquinolinone Bicyclic Core. J Med Chem 63:656-675 (2020) [PubMed]  Article 
Target
Name:
WD repeat-containing protein 5
Synonyms:
BIG3 | WD repeat-containing protein 5 | WD repeat-containing protein 5 (WDR5) | WD repeat-containing protein 5 (WRD5) | WDR5 | WDR5_HUMAN
Type:
Protein
Mol. Mass.:
36597.13
Organism:
Homo sapiens (Human)
Description:
P61964
Residue:
334
Sequence:
MATEEKKPETEAARAQPTPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSDC
  
Inhibitor
Name:
BDBM50520121
Synonyms:
CHEMBL4441671 | US10844044, Example 1
Type:
Small organic molecule
Emp. Form.:
C25H22Cl2FN5O
Mol. Mass.:
498.379
SMILES:
Cc1nc(F)ccc1-c1cc(Cn2ccn(C)c2=N)cc(c1)C(=O)NCc1ccc(Cl)c(Cl)c1
Structure:
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