Target
Ribosomal protein S6 kinase alpha-6
Ligand
BDBM50520173
Substrate
n/a
Meas. Tech.
ChEMBL_1879131 (CHEMBL4380525)
IC50
6110±n/a nM
Citation
 Lefranc, JSchulze, VKHillig, RCBriem, HPrinz, FMengel, AHeinrich, TBalint, JRengachari, SIrlbacher, HStöckigt, DBömer, UBader, BGradl, SNNising, CFvon Nussbaum, FMumberg, DPanne, DWengner, AM Discovery of BAY-985, a Highly Selective TBK1/IKK? Inhibitor. J Med Chem 63:601-612 (2020) [PubMed]  Article 
Target
Name:
Ribosomal protein S6 kinase alpha-6
Synonyms:
90 kDa ribosomal protein S6 kinase 6 | KS6A6_HUMAN | RPS6KA6 | RPS6KA6(Kin.Dom.1 - N-terminal) | RPS6KA6(Kin.Dom.2 - C-terminal) | RSK-4 | RSK4 | Ribosomal S6 Kinase 4 (RSK-4) | Ribosomal S6 kinase 4 | Ribosomal protein S6 kinase alpha 6 | Ribosomal protein S6 kinase alpha 6 (RSK4) | Ribosomal protein S6 kinase alpha-6 | S6K-alpha 6 | p90-RSK 6 | p90RSK | pp90RSK4
Type:
Serine/threonine-protein kinase
Mol. Mass.:
83868.06
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
745
Sequence:
MLPFAPQDEPWDREMEVFSGGGASSGEVNGLKMVDEPMEEGEADSCHDEGVVKEIPITHHVKEGYEKADPAQFELLKVLGQGSFGKVFLVRKKTGPDAGQLYAMKVLKKASLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDVFTRLSKEVLFTEEDVKFYLAELALALDHLHQLGIVYRDLKPENILLDEIGHIKLTDFGLSKESVDQEKKAYSFCGTVEYMAPEVVNRRGHSQSADWWSYGVLMFEMLTGTLPFQGKDRNETMNMILKAKLGMPQFLSAEAQSLLRMLFKRNPANRLGSEGVEEIKRHLFFANIDWDKLYKREVQPPFKPASGKPDDTFCFDPEFTAKTPKDSPGLPASANAHQLFKGFSFVATSIAEEYKITPITSANVLPIVQINGNAAQFGEVYELKEDIGVGSYSVCKRCIHATTNMEFAVKIIDKSKRDPSEEIEILMRYGQHPNIITLKDVFDDGRYVYLVTDLMKGGELLDRILKQKCFSEREASDILYVISKTVDYLHCQGVVHRDLKPSNILYMDESASADSIRICDFGFAKQLRGENGLLLTPCYTANFVAPEVLMQQGYDAACDIWSLGVLFYTMLAGYTPFANGPNDTPEEILLRIGNGKFSLSGGNWDNISDGAKDLLSHMLHMDPHQRYTAEQILKHSWITHRDQLPNDQPKRNDVSHVVKGAMVATYSALTHKTFQPVLEPVAASSLAQRRSMKKRTSTGL
  
Inhibitor
Name:
BDBM50520173
Synonyms:
CHEMBL4538591 | US10894784, Example 179.02
Type:
Small organic molecule
Emp. Form.:
C26H27ClF3N9O
Mol. Mass.:
574
SMILES:
CN(C)c1ncnc(-c2ccc3nc(Nc4cc(CN5CCN(CC5)C(=O)CC(F)(F)F)ccn4)[nH]c3c2)c1Cl
Structure:
Search PDB for entries with ligand similarity: