Reaction Details Report a problem with these data
Target
Somatostatin receptor type 2
Ligand
BDBM50075272
Substrate
n/a
Meas. Tech.
ChEMBL_200681 (CHEMBL807093)
Ki
8.50±n/a nM
Citation
 Pasternak, A; Pan, Y; Marino, D; Sanderson, PE; Mosley, R; Rohrer, SP; Birzin, ET; Huskey, SE; Jacks, T; Schleim, KD; Cheng, K; Schaeffer, JM; Patchett, AA; Yang, L Potent, orally bioavailable somatostatin agonists: good absorption achieved by urea backbone cyclization. Bioorg Med Chem Lett 9:491-6 (1999) [PubMed]  Article 
Target
Name:
Somatostatin receptor type 2
Synonyms:
SOMATOSTATIN SST2 | SRIF-1 | SS-2-R | SS2-R | SS2R | SSR2_HUMAN | SSTR2 | Somatostatin receptor type 2 (SSTR2)
Type:
Enzyme
Mol. Mass.:
41344.94
Organism:
Homo sapiens (Human)
Description:
P30874
Residue:
369
Sequence:
MDMADEPLNGSHTWLSIPFDLNGSVVSTNTSNQTEPYYDLTSNAVLTFIYFVVCIIGLCGNTLVIYVILRYAKMKTITNIYILNLAIADELFMLGLPFLAMQVALVHWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMIYAGLRSNQWGRSSCTINWPGESGAWYTGFIIYTFILGFLVPLTIICLCYLFIIIKVKSSGIRVGSSKRKKSEKKVTRMVSIVVAVFIFCWLPFYIFNVSSVSMAISPTPALKGMFDFVVVLTYANSCANPILYAFLSDNFKKSFQNVLCLVKVSGTDDGERSDSKQDKSRLNETTETQRTLLNGDLQTSI
  
Inhibitor
Name:
BDBM50075272
Synonyms:
(2R,3S)-N-(5-Amino-[1,3]dioxan-2-ylmethyl)-2-[3-(3,3-diphenyl-propyl)-2-oxo-imidazolidin-1-yl]-3-(1H-indol-3-yl)-butyramide | CHEMBL148309
Type:
Small organic molecule
Emp. Form.:
C35H41N5O4
Mol. Mass.:
595.7311
SMILES:
C[C@H]([C@@H](N1CCN(CCC(c2ccccc2)c2ccccc2)C1=O)C(=O)NC[C@H]1OC[C@H](N)CO1)c1c[nH]c2ccccc12 |wU:2.2,28.30,wD:31.34,1.0,(-.69,3.24,;-.68,1.7,;.66,.93,;1.98,1.7,;1.97,3.24,;4.64,3.26,;4.65,1.72,;6,.97,;7.31,1.74,;8.66,.98,;9.99,1.77,;11.32,1,;12.65,1.77,;12.65,3.33,;11.29,4.08,;9.97,3.31,;8.66,-.56,;7.33,-1.33,;7.35,-2.87,;8.69,-3.62,;10.02,-2.83,;10.01,-1.31,;3.32,.95,;3.34,-.59,;.66,-.61,;2.2,-.61,;-.12,-1.94,;.64,-3.27,;-.14,-4.6,;.63,-5.93,;-.16,-7.26,;-1.7,-7.26,;-2.49,-8.57,;-2.45,-5.91,;-1.67,-4.58,;-2.01,.91,;-2,-.61,;-3.33,-1.41,;-4.66,-.64,;-6,-1.41,;-7.33,-.64,;-7.33,.91,;-6,1.68,;-4.66,.91,)|
Structure:
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