Target
GTPase KRas
Ligand
BDBM50521250
Substrate
n/a
Meas. Tech.
ChEMBL_1883819 (CHEMBL4385318)
IC50
12±n/a nM
Citation
 Kargbo, RB Inhibitors of G12C Mutant Ras Proteins for the Treatment of Cancers. ACS Med Chem Lett 10:10-11 (2019) [PubMed]  Article 
Target
Name:
GTPase KRas
Synonyms:
GTPase KRas, N-terminally processed | K-Ras 2 | KRAS | KRAS2 | Ki-Ras | RASK2 | RASK_HUMAN | c-K-ras | c-Ki-ras
Type:
PROTEIN
Mol. Mass.:
21656.10
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1476955
Residue:
189
Sequence:
MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM
  
Inhibitor
Name:
BDBM50521250
Synonyms:
CHEMBL4475526
Type:
Small organic molecule
Emp. Form.:
C24H21ClN6O2
Mol. Mass.:
460.916
SMILES:
[H][C@@]12CN(CCN1c1ncnc3cc(c(Cl)c(OC2)c13)-c1c(C)ccc2[nH]ncc12)C(=O)C=C |r,wU:1.0,(15.23,-3.53,;14.46,-4.86,;15.98,-4.73,;16.85,-6,;16.19,-7.38,;14.67,-7.5,;13.8,-6.25,;12.38,-6.49,;12.43,-7.97,;11.09,-8.75,;9.76,-7.97,;9.76,-6.43,;8.43,-5.67,;8.42,-4.15,;9.75,-3.37,;9.75,-1.82,;11.08,-4.13,;12.28,-3.16,;13.78,-3.48,;11.1,-5.66,;7.08,-3.38,;7.08,-1.84,;8.41,-1.06,;5.74,-1.08,;4.4,-1.86,;4.42,-3.41,;3.28,-4.45,;3.92,-5.85,;5.46,-5.68,;5.76,-4.17,;18.39,-5.87,;19.05,-4.48,;19.27,-7.14,;20.8,-7.02,)|
Structure:
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