Reaction Details
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Large neutral amino acids transporter small subunit 1
Ligand
BDBM18073
Substrate
n/a
Meas. Tech.
ChEMBL_1885219 (CHEMBL4386801)
IC50
69000±n/a nM
Citation
Hall, C; Wolfe, H; Wells, A; Chien, HC; Colas, C; Schlessinger, A; Giacomini, KM; Thomas, AA l-Type amino acid transporter 1 activity of 1,2,3-triazolyl analogs of l-histidine and l-tryptophan. Bioorg Med Chem Lett 29:2254-2258 (2019) [PubMed] Article More Info.:
Target
Name:
Large neutral amino acids transporter small subunit 1
Synonyms:
4F2 LC | 4F2 light chain | 4F2LC | CD98 light chain | CD98LC | CD98LC | Integral membrane protein E16 | L-type amino acid transporter 1 | LAT1 | LAT1_HUMAN | Large neutral amino acids transporter small subunit 1 | MPE16 | SLC7A5 | Solute carrier family 7 member 5 | hLAT1 | y+ system cationic amino acid transporter
Type:
PROTEIN
Mol. Mass.:
55013.61
Organism:
Homo sapiens (Human)
Description:
ChEMBL_100160
Residue:
507
Sequence:
MAGAGPKRRALAAPAAEEKEEAREKMLAAKSADGSAPAGEGEGVTLQRNITLLNGVAIIVGTIIGSGIFVTPTGVLKEAGSPGLALVVWAACGVFSIVGALCYAELGTTISKSGGDYAYMLEVYGSLPAFLKLWIELLIIRPSSQYIVALVFATYLLKPLFPTCPVPEEAAKLVACLCVLLLTAVNCYSVKAATRVQDAFAAAKLLALALIILLGFVQIGKGDVSNLDPNFSFEGTKLDVGNIVLALYSGLFAYGGWNYLNFVTEEMINPYRNLPLAIIISLPIVTLVYVLTNLAYFTTLSTEQMLSSEAVAVDFGNYHLGVMSWIIPVFVGLSCFGSVNGSLFTSSRLFFVGSREGHLPSILSMIHPQLLTPVPSLVFTCVMTLLYAFSKDIFSVINFFSFFNWLCVALAIIGMIWLRHRKPELERPIKVNLALPVFFILACLFLIAVSFWKTPVECGIGFTIILSGLPVYFFGVWWKNKPKWLLQGIFSTTVLCQKLMQVVPQET
Inhibitor
Name:
BDBM18073
Synonyms:
(2S)-2-amino-3-phenylpropanoic acid | CHEMBL301523 | L-[2,3,4,5,6-3H]phenylalanine | L-phenylalanine | Phenylalanine | US11021454, Compound L-phe
Type:
Amino Acid
Emp. Form.:
C9H11NO2
Mol. Mass.:
165.1891
SMILES:
N[C@@H](Cc1ccccc1)C(O)=O
Structure:
