Target
Carbonic anhydrase 2
Ligand
BDBM50523342
Substrate
n/a
Meas. Tech.
ChEMBL_1890033 (CHEMBL4391787)
Ki
0.030000±n/a nM
Citation
 Krasavin, MShetnev, ABaykov, SKalinin, SNocentini, ASharoyko, VPoli, GTuccinardi, TKorsakov, MTennikova, TBSupuran, CT Pyridazinone-substituted benzenesulfonamides display potent inhibition of membrane-bound human carbonic anhydrase IX and promising antiproliferative activity against cancer cell lines. Eur J Med Chem 168:301-314 (2019) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 2
Synonyms:
CA-II | CA2 | CAC | CAH2_HUMAN | Carbonate dehydratase II | Carbonic anhydrase 2 (CA II) | Carbonic anhydrase 2 (CA-II) | Carbonic anhydrase 2 (Recombinant CA II) | Carbonic anhydrase C | Carbonic anhydrase II (CA II) | Carbonic anhydrase II (CA-II) | Carbonic anhydrase II (CAII) | Carbonic anhydrase II (hCA II) | Carbonic anhydrase isoenzyme II (hCA II)
Type:
Enzyme
Mol. Mass.:
29250.71
Organism:
Homo sapiens (Human)
Description:
P00918
Residue:
260
Sequence:
MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK
  
Inhibitor
Name:
BDBM50523342
Synonyms:
CHEMBL4527427
Type:
Small organic molecule
Emp. Form.:
C15H13N3O3S
Mol. Mass.:
315.347
SMILES:
Cc1nn(-c2ccc(cc2)S(N)(=O)=O)c(=O)c2ccccc12
Structure:
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