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Target
Proteasome subunit beta type-9
Ligand
BDBM50099954
Substrate
n/a
Meas. Tech.
ChEMBL_1892570 (CHEMBL4394491)
IC50
140±n/a nM
Citation
 Lee, MJ; Bhattarai, D; Yoo, J; Miller, Z; Park, JE; Lee, S; Lee, W; Driscoll, JJ; Kim, KB Development of Novel Epoxyketone-Based Proteasome Inhibitors as a Strategy To Overcome Cancer Resistance to Carfilzomib and Bortezomib. J Med Chem 62:4444-4455 (2019) [PubMed]  Article 
Target
Name:
Proteasome subunit beta type-9
Synonyms:
LMP2 | Low molecular mass protein 2 | Macropain chain 7 | Multicatalytic endopeptidase complex chain 7 | PSB9_HUMAN | PSMB6i | PSMB9 | Proteasome chain 7 | Proteasome subunit beta-1i | RING12 | Really interesting new gene 12 protein
Type:
PROTEIN
Mol. Mass.:
23256.49
Organism:
Homo sapiens (Human)
Description:
ChEMBL_106197
Residue:
219
Sequence:
MLRAGAPTGDLPRAGEVHTGTTIMAVEFDGGVVMGSDSRVSAGEAVVNRVFDKLSPLHERIYCALSGSAADAQAVADMAAYQLELHGIELEEPPLVLAAANVVRNISYKYREDLSAHLMVAGWDQREGGQVYGTLGGMLTRQPFAIGGSGSTFIYGYVDAAYKPGMSPEECRRFTTDAIALAMSRDGSSGGVIYLVTITAAGVDHRVILGNELPKFYDE
  
Inhibitor
Name:
BDBM50099954
Synonyms:
CHEMBL3319605
Type:
Small organic molecule
Emp. Form.:
C25H48N2O5Si
Mol. Mass.:
484.7445
SMILES:
CCCCCCC(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)[C@@]1(CO[Si](C)(C)C(C)(C)C)CO1 |r|
Structure:
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