Reaction Details Report a problem with these data
Target
Acetylcholine receptor subunit epsilon
Ligand
BDBM50524709
Substrate
n/a
Meas. Tech.
ChEMBL_1894505 (CHEMBL4396426)
IC50
40700±n/a nM
Citation
 Huang, W; Liang, M; Li, Q; Zheng, X; Zhang, C; Wang, Q; Tang, L; Zhang, Z; Wang, B; Shen, Z Development of the "hidden" multifunctional agents for Alzheimer's disease. Eur J Med Chem 177:247-258 (2019) [PubMed]  Article 
Target
Name:
Acetylcholine receptor subunit epsilon
Synonyms:
ACHE_RAT | Acetylcholine receptor protein epsilon chain | Achre | Chrne
Type:
PROTEIN
Mol. Mass.:
54930.09
Organism:
Rattus norvegicus
Description:
ChEMBL_1292388
Residue:
494
Sequence:
MTMALLGTLLLLALFGRSQGKNEELSLYHHLFDNYDPECRPVRRPEDTVTITLKVTLTNLISLNEKEETLTTSVWIGIEWQDYRLNFSKDDFAGVEILRVPSEHVWLPEIVLENNIDGQFGVAYDCNVLVYEGGSVSWLPPAIYRSTCAVEVTYFPFDWQNCSLIFRSQTYNAEEVELIFAVDDDGNAINKIDIDTAAFTENGEWAIDYCPGMIRHYEGGSTEDPGETDVIYTLIIRRKPLFYVINIIVPCVLISGLVLLAYFLPAQAGGQKCTVSINVLLAQTVFLFLIAQKIPETSLSVPLLGRYLIFVMVVATLIVMNCVIVLNVSLRTPTTHATSPRLRQILLELLPRLLGLSPPPEDPGAASPARRASSVGILLRAEELILKKPRSELVFEGQRHRHGTWTAAALCQNLGAAAPEVRCCVDAVNFVAESTRDQEATGEELSDWVRMGKALDNVCFWAALVLFSVGSTLIFLGGYFNQVPDLPYPPCIQP
  
Inhibitor
Name:
BDBM50524709
Synonyms:
CHEMBL4471688
Type:
Small organic molecule
Emp. Form.:
C18H25N3O2
Mol. Mass.:
315.41
SMILES:
CCN(C)C(C)c1cc(OC(=O)N(C)CC)c2ncccc2c1
Structure:
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