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Target
Hypoxia-inducible factor 1-alpha inhibitor
Ligand
BDBM26107
Substrate
n/a
Meas. Tech.
ChEMBL_1894961 (CHEMBL4396996)
Kd
83000±n/a nM
Citation
 Li, Z; You, Q; Zhang, X Small-Molecule Modulators of the Hypoxia-Inducible Factor Pathway: Development and Therapeutic Applications. J Med Chem 62:5725-5749 (2019) [PubMed]  Article 
Target
Name:
Hypoxia-inducible factor 1-alpha inhibitor
Synonyms:
FIH1 | HIF1AN | HIF1N_HUMAN | Hypoxia-inducible factor 1 (FIH) | Hypoxia-inducible factor 1-alpha inhibitor
Type:
Enzyme
Mol. Mass.:
40278.92
Organism:
Homo sapiens (Human)
Description:
Q9NWT6
Residue:
349
Sequence:
MAATAAEAVASGSGEPREEAGALGPAWDESQLRSYSFPTRPIPRLSQSDPRAEELIENEEPVVLTDTNLVYPALKWDLEYLQENIGNGDFSVYSASTHKFLYYDEKKMANFQNFKPRSNREEMKFHEFVEKLQDIQQRGGEERLYLQQTLNDTVGRKIVMDFLGFNWNWINKQQGKRGWGQLTSNLLLIGMEGNVTPAHYDEQQNFFAQIKGYKRCILFPPDQFECLYPYPVHHPCDRQSQVDFDNPDYERFPNFQNVVGYETVVGPGDVLYIPMYWWHHIESLLNGGITITVNFWYKGAPTPKRIEYPLKAHQKVAIMRNIEKMLGEALGNPQEVGPLLNTMIKGRYN
  
Inhibitor
Name:
BDBM26107
Synonyms:
(2R)-2-(formamidoformic acid)-3-phenylpropanoic acid | N-(carboxycarbonyl)-D-phenylalanine | N-Oxalyl-D-phenylalanine, 1b
Type:
Small organic molecule
Emp. Form.:
C11H11NO5
Mol. Mass.:
237.2087
SMILES:
OC(=O)[C@@H](Cc1ccccc1)NC(=O)C(O)=O |r|
Structure:
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