Reaction Details Report a problem with these data
Target
Gamma-aminobutyric acid receptor subunit rho-1
Ligand
BDBM50525186
Substrate
n/a
Meas. Tech.
ChEMBL_1896016 (CHEMBL4398051)
IC50
300000±n/a nM
Citation
 Giraudo, A; Krall, J; Bavo, F; Nielsen, B; Kongstad, KT; Rolando, B; De Blasio, R; Gloriam, DE; Löffler, R; Thiesen, L; Harpsøe, K; Frydenvang, K; Boschi, D; Wellendorph, P; Lolli, ML; Jensen, AA; Frølund, B Five-Membered N-Heterocyclic Scaffolds as Novel Amino Bioisosteres at ?-Aminobutyric Acid (GABA) Type A Receptors and GABA Transporters. J Med Chem 62:5797-5809 (2019) [PubMed]  Article 
Target
Name:
Gamma-aminobutyric acid receptor subunit rho-1
Synonyms:
GABA receptor rho-1 subunit | GABA-C receptor | GABRR1 | GBRR1_HUMAN
Type:
PROTEIN
Mol. Mass.:
55892.34
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1456653
Residue:
479
Sequence:
MLAVPNMRFGIFLLWWGWVLATESRMHWPGREVHEMSKKGRPQRQRREVHEDAHKQVSPILRRSPDITKSPLTKSEQLLRIDDHDFSMRPGFGGPAIPVGVDVQVESLDSISEVDMDFTMTLYLRHYWKDERLSFPSTNNLSMTFDGRLVKKIWVPDMFFVHSKRSFIHDTTTDNVMLRVQPDGKVLYSLRVTVTAMCNMDFSRFPLDTQTCSLEIESYAYTEDDLMLYWKKGNDSLKTDERISLSQFLIQEFHTTTKLAFYSSTGWYNRLYINFTLRRHIFFFLLQTYFPATLMVMLSWVSFWIDRRAVPARVPLGITTVLTMSTIITGVNASMPRVSYIKAVDIYLWVSFVFVFLSVLEYAAVNYLTTVQERKEQKLREKLPCTSGLPPPRTAMLDGNYSDGEVNDLDNYMPENGEKPDRMMVQLTLASERSSPQRKSQRSSYVSMRIDTHAIDKYSRIIFPAAYILFNLIYWSIFS
  
Inhibitor
Name:
BDBM50525186
Synonyms:
CHEMBL4566832
Type:
Small organic molecule
Emp. Form.:
C6H10N2O2S
Mol. Mass.:
174.221
SMILES:
CC1(CC(O)=O)CSC(N)=N1 |c:9|
Structure:
Search PDB for entries with ligand similarity: