Reaction Details Report a problem with these data
Target
Deoxyhypusine hydroxylase
Ligand
BDBM66087
Substrate
n/a
Meas. Tech.
ChEMBL_1898739 (CHEMBL4400854)
IC50
5000±n/a nM
Citation
 Jiang, Z; You, Q; Zhang, X Medicinal chemistry of metal chelating fragments in metalloenzyme active sites: A perspective. Eur J Med Chem 165:172-197 (2019) [PubMed]  Article 
Target
Name:
Deoxyhypusine hydroxylase
Synonyms:
1.14.99.29 | DOHH | DOHH_HUMAN | Deoxyhypusine dioxygenase | Deoxyhypusine hydroxylase | Deoxyhypusine monooxygenase | HEAT-like repeat-containing protein 1 | HLRC1 | Synonyms=HLRC1 | hDOHH
Type:
PROTEIN
Mol. Mass.:
32886.24
Organism:
Homo sapiens
Description:
ChEMBL_119191
Residue:
302
Sequence:
MVTEQEVDAIGQTLVDPKQPLQARFRALFTLRGLGGPGAIAWISQAFDDDSALLKHELAYCLGQMQDARAIPMLVDVLQDTRQEPMVRHEAGEALGAIGDPEVLEILKQYSSDPVIEVAETCQLAVRRLEWLQQHGGEPAAGPYLSVDPAPPAEERDVGRLREALLDESRPLFERYRAMFALRNAGGEEAALALAEGLHCGSALFRHEVGYVLGQLQHEAAVPQLAAALARCTENPMVRHECAEALGAIARPACLAALQAHADDPERVVRESCEVALDMYEHETGRAFQYADGLEQLRGAPS
  
Inhibitor
Name:
BDBM66087
Synonyms:
2-aminoethanol;6-cyclohexyl-1-hydroxy-4-methyl-2-pyridinone | 2-aminoethanol;6-cyclohexyl-1-hydroxy-4-methyl-2-pyridone | 2-aminoethanol;6-cyclohexyl-1-hydroxy-4-methylpyridin-2-one | 2-azanylethanol;6-cyclohexyl-4-methyl-1-oxidanyl-pyridin-2-one | Ciclopirox | Ciclopirox ethanolamine | MLS002153867 | SMR001233223 | cid_38911
Type:
Small organic molecule
Emp. Form.:
C12H17NO2
Mol. Mass.:
207.2689
SMILES:
Cc1cc(C2CCCCC2)n(O)c(=O)c1
Structure:
Search PDB for entries with ligand similarity: