Target
Retinoic acid receptor alpha
Ligand
BDBM50048292
Substrate
n/a
Meas. Tech.
ChEMBL_1899797 (CHEMBL4401912)
EC50
9.2±n/a nM
Citation
 Goncalves, MBClarke, EJarvis, CIBarret Kalindjian, SPitcher, TGrist, JHobbs, CCarlstedt, TJack, JBrown, JTMills, MMumford, PBorthwick, ADCorcoran, JPT Discovery and lead optimisation of a potent, selective and orally bioavailable RAR? agonist for the potential treatment of nerve injury. Bioorg Med Chem Lett 29:995-1000 (2019) [PubMed]  Article 
Target
Name:
Retinoic acid receptor alpha
Synonyms:
Nr1b1 | RARA_MOUSE | Rara
Type:
PROTEIN
Mol. Mass.:
50742.79
Organism:
Mus musculus
Description:
ChEMBL_195182
Residue:
462
Sequence:
MASNSSSCPTPGGGHLNGYPVPPYAFFFPPMLGGLSPPGALTSLQHQLPVSGYSTPSPATIETQSSSSEEIVPSPPSPPPLPRIYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQKCFDVGMSKESVRNDRNKKKKEAPKPECSESYTLTPEVGELIEKVRKAHQETFPALCQLGKYTTNNSSEQRVSLDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFANQLLPLEMDDAETGLLSAICLICGDRQDLEQPDKVDMLQEPLLEALKVYVRKRRPSRPHMFPKMLMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLENSEGLDTLSGQSGGGTRDGGGLAPPPGSCSPSLSPSSHRSSPATQSP
  
Inhibitor
Name:
BDBM50048292
Synonyms:
6-[4-Methoxy-3-(1-methyl-cyclohexyl)-phenyl]-naphthalene-2-carboxylic acid | CHEMBL345298
Type:
Small organic molecule
Emp. Form.:
C25H26O3
Mol. Mass.:
374.4721
SMILES:
COc1ccc(cc1C1(C)CCCCC1)-c1ccc2cc(ccc2c1)C(O)=O
Structure:
Search PDB for entries with ligand similarity: