Target
Histamine H1 receptor
Ligand
BDBM50073179
Substrate
n/a
Meas. Tech.
ChEMBL_1908194 (CHEMBL4410552)
IC50
1.8±n/a nM
Citation
 Li, FXu, QZhu, QChu, ZLin, GMo, JZhao, YLi, JHe, GXu, Y Design, synthesis and biological evaluation of novel desloratadine derivatives with anti-inflammatory and H Bioorg Med Chem Lett 29:0 (2019) [PubMed]  Article 
Target
Name:
Histamine H1 receptor
Synonyms:
H1R | HH1R | HISTAMINE H1 | HRH1 | HRH1_HUMAN
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
55808.72
Organism:
Homo sapiens (Human)
Description:
Cell pellets from SK-N-MC cells transfected with human H1 receptor were used in binding assay.
Residue:
487
Sequence:
MSLPNSSCLLEDKMCEGNKTTMASPQLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHTVGNLYIVSLSVADLIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLRYLKYRTKTRASATILGAWFLSFLWVIPILGWNHFMQQTSVRREDKCETDFYDVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLRPENPKGDAKKPGKESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKLYCFPLDIVHMQAAAEGSSRDYVAVNRSHGQLKTDEQGLNTHGASEISEDQMLGDSQSFSRTDSDTTTETAPGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKAAKQLGFIMAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFKRILHIRS
  
Inhibitor
Name:
BDBM50073179
Synonyms:
8-Chloro-11-piperidin-4-ylidene-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine | CHEMBL1172 | Clarinex | Claritin | Claritin-D | DESLORATADINE | SCH-34117 | US9138431, DESLORATADINE (Clarinex) | US9333199, DESLORATADINE (Clarinex)
Type:
Small organic molecule
Emp. Form.:
C19H19ClN2
Mol. Mass.:
310.821
SMILES:
Clc1ccc2c(-[#6]-[#6]-c3cccnc3\[#6]-2=[#6]-2/[#6]-[#6]-[#7]-[#6]-[#6]-2)c1
Structure:
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