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Target
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta
Ligand
BDBM50019865
Substrate
n/a
Meas. Tech.
ChEMBL_1909754 (CHEMBL4412200)
IC50
21±n/a nM
Citation
 Chen, D; Chen, Y; Lian, F; Chen, L; Li, Y; Cao, D; Wang, X; Chen, L; Li, J; Meng, T; Huang, M; Geng, M; Shen, J; Zhang, N; Xiong, B Fragment-based drug discovery of triazole inhibitors to block PDE?-RAS protein-protein interaction. Eur J Med Chem 163:597-609 (2019) [PubMed]  Article 
Target
Name:
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta
Synonyms:
3',5'-cyclic phosphodiesterase | GMP-PDE delta | PDE6D | PDE6D_HUMAN | PDED | Protein p17 | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta
Type:
PROTEIN
Mol. Mass.:
17418.30
Organism:
Homo sapiens (Human)
Description:
ChEMBL_105761
Residue:
150
Sequence:
MSAKDERAREILRGFKLNWMNLRDAETGKILWQGTEDLSVPGVEHEARVPKKILKCKAVSRELNFSSTEQMEKFRLEQKVYFKGQCLEEWFFEFGFVIPNSTNTWQSLIEAAPESQMMPASVLTGNVIIETKFFDDDLLVSTSRVRLFYV
  
Inhibitor
Name:
BDBM50019865
Synonyms:
CHEMBL3286929
Type:
Small organic molecule
Emp. Form.:
C40H37N5O
Mol. Mass.:
603.7547
SMILES:
C(Oc1ccc(cc1)-c1nc2ccccc2n1Cc1ccccc1)[C@H](C1CCNCC1)n1c(nc2ccccc12)-c1ccccc1 |r|
Structure:
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