Reaction Details Report a problem with these data
Target
Chymotrypsinogen A
Ligand
BDBM50085361
Substrate
n/a
Meas. Tech.
ChEBML_215994
IC50
5200±n/a nM
Citation
 Hayashi, Y; Iijima, K; Katada, J; Kiso, Y Structure-activity relationship studies of chloromethyl ketone derivatives for selective human chymase inhibitors. Bioorg Med Chem Lett 10:199-201 (2000) [PubMed]  Article 
Target
Name:
Chymotrypsinogen A
Synonyms:
Alpha-chymotrypsin | CTRA_BOVIN | Chymotrypsin A | Chymotrypsin A chain A | Chymotrypsin A chain B | Chymotrypsin A chain C | Chymotrypsinogen A | alpha-Chymotrypsin (α-Chymotrypsin)
Type:
Serine protease
Mol. Mass.:
25670.88
Organism:
Bos taurus (bovine)
Description:
n/a
Residue:
245
Sequence:
CGVPAIQPVLSGLSRIVNGEEAVPGSWPWQVSLQDKTGFHFCGGSLINENWVVTAAHCGVTTSDVVVAGEFDQGSSSEKIQKLKIAKVFKNSKYNSLTINNDITLLKLSTAASFSQTVSAVCLPSASDDFAAGTTCVTTGWGLTRYTNANTPDRLQQASLPLLSNTNCKKYWGTKIKDAMICAGASGVSSCMGDSGGPLVCKKNGAWTLVGIVSWGSSTCSTSTPGVYARVTALVNWVQQTLAAN
  
Inhibitor
Name:
BDBM50085361
Synonyms:
CHEMBL59998 | N-((S)-1-Benzyl-3-chloro-2-oxo-propyl)-3-(3-hydroxy-phenyl)-propionamide
Type:
Small organic molecule
Emp. Form.:
C19H20ClNO3
Mol. Mass.:
345.82
SMILES:
Oc1cccc(CCC(=O)N[C@@H](Cc2ccccc2)C(=O)CCl)c1
Structure:
Search PDB for entries with ligand similarity: