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Target
Serine--tRNA ligase
Ligand
BDBM50339906
Substrate
n/a
Meas. Tech.
ChEMBL_1914051 (CHEMBL4416634)
IC50
210±n/a nM
Citation
Cain, R; Salimraj, R; Punekar, AS; Bellini, D; Fishwick, CWG; Czaplewski, L; Scott, DJ; Harris, G; Dowson, CG; Lloyd, AJ; Roper, DI Structure-Guided Enhancement of Selectivity of Chemical Probe Inhibitors Targeting Bacterial Seryl-tRNA Synthetase. J Med Chem 62:9703-9717 (2019) [PubMed] Article
More Info.:
Target
Name:
Serine--tRNA ligase
Synonyms:
6.1.1.11 | SYS_ECOLI | SerRS | Serine--tRNA ligase | Seryl-tRNA synthetase | Seryl-tRNA(Ser/Sec) synthetase | serS
Type:
PROTEIN
Mol. Mass.:
48404.41
Organism:
Escherichia coli (strain K12)
Description:
ChEMBL_117814
Residue:
430
Sequence:
MLDPNLLRNEPDAVAEKLARRGFKLDVDKLGALEERRKVLQVKTENLQAERNSRSKSIGQAKARGEDIEPLRLEVNKLGEELDAAKAELDALQAEIRDIALTIPNLPADEVPVGKDENDNVEVSRWGTPREFDFEVRDHVTLGEMHSGLDFAAAVKLTGSRFVVMKGQIARMHRALSQFMLDLHTEQHGYSENYVPYLVNQDTLYGTGQLPKFAGDLFHTRPLEEEADTSNYALIPTAEVPLTNLVRGEIIDEDDLPIKMTAHTPCFRSEAGSYGRDTRGLIRMHQFDKVEMVQIVRPEDSMAALEEMTGHAEKVLQLLGLPYRKIILCTGDMGFGACKTYDLEVWIPAQNTYREISSCSNVWDFQARRMQARCRSKSDKKTRLVHTLNGSGLAVGRTLVAVMENYQQADGRIEVPEVLRPYMNGLEYIG
Inhibitor
Name:
BDBM50339906
Synonyms:
((2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl(S)-2-amino-3-hydroxypropanoylsulfamate | 5'-O-(N-(L-SERYL)-SULFAMOYL)ADENOSINE | CHEMBL1163070 | SerSA
Type:
Small organic molecule
Emp. Form.:
C13H19N7O8S
Mol. Mass.:
433.397
SMILES:
N[C@@H](CO)C(=O)NS(=O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12 |r|