Reaction Details Report a problem with these data
Target
Adenosine receptor A2b
Ligand
BDBM50531447
Substrate
n/a
Meas. Tech.
ChEMBL_1920100 (CHEMBL4422945)
IC50
2.4±n/a nM
Citation
 Härter, M; Kalthof, B; Delbeck, M; Lustig, K; Gerisch, M; Schulz, S; Kast, R; Meibom, D; Lindner, N Novel non-xanthine antagonist of the A Eur J Med Chem 163:763-778 (2019) [PubMed]  Article 
Target
Name:
Adenosine receptor A2b
Synonyms:
AA2BR_HUMAN | ADENOSINE A2B | ADORA2B | Adenosine receptor A2B (A2B) | Adenosine receptors A2b | Adenosine receptors; A2a & A2b
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
36341.22
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
332
Sequence:
MLLETQDALYVALELVIAALSVAGNVLVCAAVGTANTLQTPTNYFLVSLAAADVAVGLFAIPFAITISLGFCTDFYGCLFLACFVLVLTQSSIFSLLAVAVDRYLAICVPLRYKSLVTGTRARGVIAVLWVLAFGIGLTPFLGWNSKDSATNNCTEPWDGTTNESCCLVKCLFENVVPMSYMVYFNFFGCVLPPLLIMLVIYIKIFLVACRQLQRTELMDHSRTTLQREIHAAKSLAMIVGIFALCWLPVHAVNCVTLFQPAQGKNKPKWAMNMAILLSHANSVVNPIVYAYRNRDFRYTFHKIISRYLLCQADVKSGNGQAGVQPALGVGL
  
Inhibitor
Name:
BDBM50531447
Synonyms:
CHEMBL4569909
Type:
Small organic molecule
Emp. Form.:
C23H26N4O3S
Mol. Mass.:
438.543
SMILES:
COCCn1c2sc(Cc3nc[nH]c3C)c(C)c2c(=O)n(CCc2ccccc2)c1=O
Structure:
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