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Target
Acyl-protein thioesterase 1
Ligand
BDBM119799
Substrate
n/a
Meas. Tech.
ChEMBL_1928057 (CHEMBL4431129)
IC50
3052±n/a nM
Citation
 Pissarnitski, DA; Zhao, Z; Cole, D; Wu, WL; Domalski, M; Clader, JW; Scapin, G; Voigt, J; Soriano, A; Kelly, T; Powles, MA; Yao, Z; Burnett, DA Scaffold-hopping from xanthines to tricyclic guanines: A case study of dipeptidyl peptidase 4 (DPP4) inhibitors. Bioorg Med Chem 24:5534-5545 (2016) [PubMed]  Article 
Target
Name:
Acyl-protein thioesterase 1
Synonyms:
Acyl-protein thioesterase 1/2 | Apt1 | LYPA1_RAT | Lypla1 | Lysosomal phospholipase A1
Type:
PROTEIN
Mol. Mass.:
24708.49
Organism:
Rattus norvegicus
Description:
ChEMBL_12731
Residue:
230
Sequence:
MCGNNMSAPMPAVVPAARKATAAVIFLHGLGDTGHGWAEAFAGIKSSHIKYICPHAPVMPVTLNMSMMMPSWFDIIGLSPDSQEDESGIKQAAETVKALIDQEVKNGIPSNRIILGGFSQGGALSLYTALTTQQKLAGVTALSCWLPLRASFSQGPINSANRDISVLQCHGDCDPLVPLMFGSLTVERLKGLVNPANVTFKVYEGMMHSSCQQEMMDVKYFIDKLLPPID
  
Inhibitor
Name:
BDBM119799
Synonyms:
US8691832, 18
Type:
Small organic molecule
Emp. Form.:
C27H33N9O
Mol. Mass.:
499.6106
SMILES:
Cc1nc(CN2C3=NCCN3c3nc(N4CCC[C@@H](N)C4)n(CC4CCC4)c3C2=O)nc2ccccc12 |r,t:6|
Structure:
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