Target
L-lactate dehydrogenase A chain
Ligand
BDBM50534309
Substrate
n/a
Meas. Tech.
ChEMBL_1928156 (CHEMBL4431228)
IC50
5.0±n/a nM
Citation
 Purkey, HERobarge, KChen, JChen, ZCorson, LBDing, CZDiPasquale, AGDragovich, PSEigenbrot, CEvangelista, MFauber, BPGao, ZGe, HHitz, AHo, QLabadie, SSLai, KWLiu, WLiu, YLi, CMa, SMalek, SO'Brien, TPang, JPeterson, DSalphati, LSideris, SUltsch, MWei, BYen, IYue, QZhang, HZhou, A Cell Active Hydroxylactam Inhibitors of Human Lactate Dehydrogenase with Oral Bioavailability in Mice. ACS Med Chem Lett 7:896-901 (2016) [PubMed]  Article 
Target
Name:
L-lactate dehydrogenase A chain
Synonyms:
Cell proliferation-inducing gene 19 protein | L-lactate dehydrogenase A | L-lactate dehydrogenase A Chain | LDH muscle subunit | LDH-A | LDH-M | LDHA | LDHA_HUMAN | Lactate dehydrogenase A (LDHA) | Renal carcinoma antigen NY-REN-59
Type:
Protein
Mol. Mass.:
36694.85
Organism:
Homo sapiens (Human)
Description:
P00338::PDB Code: 4ajp
Residue:
332
Sequence:
MATLKDQLIYNLLKEEQTPQNKITVVGVGAVGMACAISILMKDLADELALVDVIEDKLKGEMMDLQHGSLFLRTPKIVSGKDYNVTANSKLVIITAGARQQEGESRLNLVQRNVNIFKFIIPNVVKYSPNCKLLIVSNPVDILTYVAWKISGFPKNRVIGSGCNLDSARFRYLMGERLGVHPLSCHGWVLGEHGDSSVPVWSGMNVAGVSLKTLHPDLGTDKDKEQWKEVHKQVVESAYEVIKLKGYTSWAIGLSVADLAESIMKNLRRVHPVSTMIKGLYGIKDDVFLSVPCILGQNGISDLVKVTLTSEEEARLKKSADTLWGIQKELQF
  
Inhibitor
Name:
BDBM50534309
Synonyms:
CHEMBL4467769
Type:
Small organic molecule
Emp. Form.:
C27H26ClN3O3S2
Mol. Mass.:
540.097
SMILES:
CC(=O)N1CCN(CC1)c1ccc(cc1)C1(CC(O)=C(Sc2ccccc2Cl)C(=O)N1)c1ccsc1 |t:20|
Structure:
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