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Target
Peptide deformylase
Ligand
BDBM50535512
Substrate
n/a
Meas. Tech.
ChEMBL_1930890 (CHEMBL4434141)
IC50
2.0±n/a nM
Citation
 Spletstoser, JT; Dreabit, J; Knox, AN; Benowitz, A; Campobasso, N; Ward, P; Cui, G; Lewandowski, T; McCloskey, L; Aubart, KM Discovery of piperazic acid peptide deformylase inhibitors with in vivo activity for respiratory tract and skin infections. Bioorg Med Chem Lett 29:2410-2414 (2019) [PubMed]  Article 
Target
Name:
Peptide deformylase
Synonyms:
DEF_STAAM | PDF | Polypeptide deformylase | def | def1 | pdf1
Type:
Enzyme
Mol. Mass.:
20556.80
Organism:
Staphylococcus aureus
Description:
P68825
Residue:
183
Sequence:
MLTMKDIIRDGHPTLRQKAAELELPLTKEEKETLIAMREFLVNSQDEEIAKRYGLRSGVGLAAPQINISKRMIAVLIPDDGSGKSYDYMLVNPKIVSHSVQEAYLPTGEGCLSVDDNVAGLVHRHNRITIKAKDIEGNDIQLRLKGYPAIVFQHEIDHLNGVMFYDHIDKNHPLQPHTDAVEV
  
Inhibitor
Name:
BDBM50535512
Synonyms:
CHEMBL4434997
Type:
Small organic molecule
Emp. Form.:
C19H28N6O4
Mol. Mass.:
404.4634
SMILES:
ON(C[C@@H](CC1CCCC1)C(=O)N1NCCC[C@H]1C(=O)Nc1ccncn1)C=O |r|
Structure:
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