Target
Hydroxycarboxylic acid receptor 2
Ligand
BDBM50541473
Substrate
n/a
Meas. Tech.
ChEMBL_1984606 (CHEMBL4618012)
IC50
65±n/a nM
Citation
 Miyazawa, YYamaguchi, TYamaguchi, MTago, KTamura, ASugiyama, DAburatani, TNishizawa, TKurikawa, NKono, K Discovery of novel pyrrole derivatives as potent agonists for the niacin receptor GPR109A. Bioorg Med Chem Lett 30:0 (2020) [PubMed]  Article 
Target
Name:
Hydroxycarboxylic acid receptor 2
Synonyms:
G-protein coupled receptor 109A | G-protein coupled receptor HM74A | GPR109A | HCA2 | HCAR2 | HCAR2_HUMAN | HM74A | Hydroxycarboxylic acid receptor 2 | NIACR1 | Niacin Receptor GPR109A | Nicotinic acid receptor 1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
41868.22
Organism:
Homo sapiens (Human)
Description:
Membranes from CHO cells expressing the recombinant human GPR109A were used in competition binding assay.
Residue:
363
Sequence:
MNRHHLQDHFLEIDKKNCCVFRDDFIVKVLPPVLGLEFIFGLLGNGLALWIFCFHLKSWKSSRIFLFNLAVADFLLIICLPFLMDNYVRRWDWKFGDIPCRLMLFMLAMNRQGSIIFLTVVAVDRYFRVVHPHHALNKISNRTAAIISCLLWGITIGLTVHLLKKKMPIQNGGANLCSSFSICHTFQWHEAMFLLEFFLPLGIILFCSARIIWSLRQRQMDRHAKIKRAITFIMVVAIVFVICFLPSVVVRIRIFWLLHTSGTQNCEVYRSVDLAFFITLSFTYMNSMLDPVVYYFSSPSFPNFFSTLINRCLQRKMTGEPDNNRSTSVELTGDPNKTRGAPEALMANSGEPWSPSYLGPTSP
  
Inhibitor
Name:
BDBM50541473
Synonyms:
CHEMBL4632359
Type:
Small organic molecule
Emp. Form.:
C22H23ClN2O4
Mol. Mass.:
414.882
SMILES:
CCCCn1cc(NC(=O)CCc2ccc3c(Cl)c(O)ccc3c2)c(c1)C(O)=O
Structure:
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