Reaction Details Report a problem with these data
Target
Hydroxycarboxylic acid receptor 2
Ligand
BDBM50541467
Substrate
n/a
Meas. Tech.
ChEMBL_1984606 (CHEMBL4618012)
IC50
290±n/a nM
Citation
 Miyazawa, Y; Yamaguchi, T; Yamaguchi, M; Tago, K; Tamura, A; Sugiyama, D; Aburatani, T; Nishizawa, T; Kurikawa, N; Kono, K Discovery of novel pyrrole derivatives as potent agonists for the niacin receptor GPR109A. Bioorg Med Chem Lett 30:0 (2020) [PubMed]  Article 
Target
Name:
Hydroxycarboxylic acid receptor 2
Synonyms:
G-protein coupled receptor 109A | G-protein coupled receptor HM74A | GPR109A | HCA2 | HCAR2 | HCAR2_HUMAN | HM74A | Hydroxycarboxylic acid receptor 2 | NIACR1 | Niacin Receptor GPR109A | Nicotinic acid receptor 1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
41868.22
Organism:
Homo sapiens (Human)
Description:
Membranes from CHO cells expressing the recombinant human GPR109A were used in competition binding assay.
Residue:
363
Sequence:
MNRHHLQDHFLEIDKKNCCVFRDDFIVKVLPPVLGLEFIFGLLGNGLALWIFCFHLKSWKSSRIFLFNLAVADFLLIICLPFLMDNYVRRWDWKFGDIPCRLMLFMLAMNRQGSIIFLTVVAVDRYFRVVHPHHALNKISNRTAAIISCLLWGITIGLTVHLLKKKMPIQNGGANLCSSFSICHTFQWHEAMFLLEFFLPLGIILFCSARIIWSLRQRQMDRHAKIKRAITFIMVVAIVFVICFLPSVVVRIRIFWLLHTSGTQNCEVYRSVDLAFFITLSFTYMNSMLDPVVYYFSSPSFPNFFSTLINRCLQRKMTGEPDNNRSTSVELTGDPNKTRGAPEALMANSGEPWSPSYLGPTSP
  
Inhibitor
Name:
BDBM50541467
Synonyms:
CHEMBL4647392
Type:
Small organic molecule
Emp. Form.:
C20H16ClNO4
Mol. Mass.:
369.798
SMILES:
OC(=O)c1ccccc1NC(=O)CCc1ccc2c(Cl)c(O)ccc2c1
Structure:
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