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Target
Beta-chimaerin
Ligand
BDBM50098227
Substrate
n/a
Meas. Tech.
ChEMBL_39037 (CHEMBL653433)
Ki
1500±n/a nM
Citation
 Roaten, JB; Kazanietz, MG; Sweatman, TW; Lothstein, L; Israel, M; Parrill, AL Molecular models of N-benzyladriamycin-14-valerate (AD 198) in complex with the phorbol ester-binding C1b domain of protein kinase C-delta. J Med Chem 44:1028-34 (2001) [PubMed]  Article 
Target
Name:
Beta-chimaerin
Synonyms:
ARHGAP3 | BCH | CHIO_HUMAN | CHN2 | Rho-GTPase-activating protein 3
Type:
PROTEIN
Mol. Mass.:
53932.03
Organism:
Homo sapiens (Human)
Description:
ChEMBL_39037
Residue:
468
Sequence:
MAASSNSSLSGSSVSSDAEEYQPPIWKSYLYQLQQEAPRPKRIICPREVENRPKYYGREFHGIISREQADELLGGVEGAYILRESQRQPGCYTLALRFGNQTLNYRLFHDGKHFVGEKRFESIHDLVTDGLITLYIETKAAEYISKMTTNPIYEHIGYATLLREKVSRRLSRSKNEPRKTNVTHEEHTAVEKISSLVRRAALTHNDNHFNYEKTHNFKVHTFRGPHWCEYCANFMWGLIAQGVRCSDCGLNVHKQCSKHVPNDCQPDLKRIKKVYCCDLTTLVKAHNTQRPMVVDICIREIEARGLKSEGLYRVSGFTEHIEDVKMAFDRDGEKADISANVYPDINIITGALKLYFRDLPIPVITYDTYSKFIDAAKISNADERLEAVHEVLMLLPPAHYETLRYLMIHLKKVTMNEKDNFMNAENLGIVFGPTLMRPPEDSTLTTLHDMRYQKLIVQILIENEDVLF
  
Inhibitor
Name:
BDBM50098227
Synonyms:
CHEMBL275750 | Pentanoic acid 2-[4-(3-benzylamino-4-hydroxy-5-methyl-cyclohexyloxy)-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydro-naphthacen-2-yl]-2-oxo-ethyl ester (AD 198)
Type:
Small organic molecule
Emp. Form.:
C40H45NO11
Mol. Mass.:
715.7854
SMILES:
CCCCC(=O)OCC(=O)[C@]1(O)C[C@@H](O[C@@H]2C[C@H](C)[C@H](O)[C@H](C2)NCc2ccccc2)c2c(O)c3C(=O)c4c(OC)cccc4C(=O)c3c(O)c2C1
Structure:
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