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Target
5-hydroxytryptamine receptor 2A
Ligand
BDBM50099255
Substrate
n/a
Meas. Tech.
ChEMBL_2277 (CHEMBL617063)
Ki
0.09±n/a nM
Citation
 Rowley, M; Hallett, DJ; Goodacre, S; Moyes, C; Crawforth, J; Sparey, TJ; Patel, S; Marwood, R; Patel, S; Thomas, S; Hitzel, L; O'Connor, D; Szeto, N; Castro, JL; Hutson, PH; MacLeod, AM 3-(4-Fluoropiperidin-3-yl)-2-phenylindoles as high affinity, selective, and orally bioavailable h5-HT(2A) receptor antagonists. J Med Chem 44:1603-14 (2001) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 2A
Synonyms:
5-HT-2 | 5-HT-2A | 5-HT2A | 5-hydroxytryptamine receptor 2A (5-HT-2A) | 5-hydroxytryptamine receptor 2A (5HT-2A) | 5-hydroxytryptamine receptor 2A (5HT2A) | 5HT2A_HUMAN | HTR2 | HTR2A | Serotonin receptor 2A
Type:
undefined
Mol. Mass.:
52607.65
Organism:
Homo sapiens (Human)
Description:
P28223
Residue:
471
Sequence:
MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV
  
Inhibitor
Name:
BDBM50099255
Synonyms:
6-Fluoro-2-(4-fluoro-phenyl)-3-piperidin-3-yl-1H-indole | 6-Fluoro-2-(4-fluorophenyl)-3-(piperidin-3-yl)-1H-indole | CHEMBL296512
Type:
Small organic molecule
Emp. Form.:
C19H18F2N2
Mol. Mass.:
312.3564
SMILES:
Fc1ccc(cc1)-c1[nH]c2cc(F)ccc2c1C1CCCNC1
Structure:
Search PDB for entries with ligand similarity: