Reaction Details Report a problem with these data
Target
Tubulin alpha-1A chain
Ligand
BDBM48563
Substrate
n/a
Meas. Tech.
ChEMBL_211875 (CHEMBL819257)
IC50
7300±n/a nM
Citation
 Xia, Y; Yang, ZY; Xia, P; Hackl, T; Hamel, E; Mauger, A; Wu, JH; Lee, KH Antitumor Agents. 211. Fluorinated 2-phenyl-4-quinolone derivatives as antimitotic antitumor agents. J Med Chem 44:3932-6 (2001) [PubMed]  Article 
Target
Name:
Tubulin alpha-1A chain
Synonyms:
TBA1A_PIG | TUBA1A | Tubulin | Tubulin alpha chain | Tubulin alpha-1A chain
Type:
Protein
Mol. Mass.:
50049.25
Organism:
Sus scrofa (Pig)
Description:
P02550
Residue:
451
Sequence:
MRECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDKTIGGGDDSFNTFFSETGAGKHVPRAVFVDLEPTVIDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIIDLVLDRIRKLADQCTGLQGFSVFHSFGGGTGSGFTSLLMERLSVDYGKKSKLEFSIYPAPQVSTAVVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLIGQIVSSITASLRFDGALNVDLTEFQTNLVPYPRAHFPLATYAPVISAEKAYHEQLSVAEITNACFEPANQMVKCDPRHGKYMACCLLYRGDVVPKDVNAAIATIKTKRTIQFVDWCPTGFKVGINYEPPTVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDMAALEKDYEEVGVDSVEGEGEEEGEEY
  
Inhibitor
Name:
BDBM48563
Synonyms:
2-phenyl-1H-quinolin-4-one | 2-phenyl-4-quinolone | 2-phenylquinolin-4-ol | CHEMBL277148 | MLS000084697 | SMR000019044 | cid_161091
Type:
Small organic molecule
Emp. Form.:
C15H11NO
Mol. Mass.:
221.2539
SMILES:
Oc1cc(nc2ccccc12)-c1ccccc1
Structure:
Search PDB for entries with ligand similarity: