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Target
Tubulin alpha-1A chain
Ligand
BDBM50041119
Substrate
n/a
Meas. Tech.
ChEMBL_212012 (CHEMBL816886)
IC50
39000±n/a nM
Citation
 Xia, Y; Yang, ZY; Xia, P; Hackl, T; Hamel, E; Mauger, A; Wu, JH; Lee, KH Antitumor Agents. 211. Fluorinated 2-phenyl-4-quinolone derivatives as antimitotic antitumor agents. J Med Chem 44:3932-6 (2001) [PubMed]  Article 
Target
Name:
Tubulin alpha-1A chain
Synonyms:
TBA1A_PIG | TUBA1A | Tubulin | Tubulin alpha chain | Tubulin alpha-1A chain
Type:
Protein
Mol. Mass.:
50049.25
Organism:
Sus scrofa (Pig)
Description:
P02550
Residue:
451
Sequence:
MRECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDKTIGGGDDSFNTFFSETGAGKHVPRAVFVDLEPTVIDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIIDLVLDRIRKLADQCTGLQGFSVFHSFGGGTGSGFTSLLMERLSVDYGKKSKLEFSIYPAPQVSTAVVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLIGQIVSSITASLRFDGALNVDLTEFQTNLVPYPRAHFPLATYAPVISAEKAYHEQLSVAEITNACFEPANQMVKCDPRHGKYMACCLLYRGDVVPKDVNAAIATIKTKRTIQFVDWCPTGFKVGINYEPPTVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDMAALEKDYEEVGVDSVEGEGEEEGEEY
  
Inhibitor
Name:
BDBM50041119
Synonyms:
2-(2-fluorophenyl)-6,7-methylenedioxyquinolin-4-one | 6-(2-Fluoro-phenyl)-5H-[1,3]dioxolo[4,5-g]quinolin-8-one | 6-(2-fluorophenyl)-[1,3]dioxolo[4,5-g]quinolin-8(5H)-one | CHEMBL280099 | NSC-656158
Type:
Small organic molecule
Emp. Form.:
C16H10FNO3
Mol. Mass.:
283.2539
SMILES:
Oc1cc(nc2cc3OCOc3cc12)-c1ccccc1F
Structure:
Search PDB for entries with ligand similarity: