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Target
Matrilysin
Ligand
BDBM50063917
Substrate
n/a
Meas. Tech.
ChEMBL_105058 (CHEMBL712197)
IC50
4.1±n/a nM
Citation
Wada, CK; Holms, JH; Curtin, ML; Dai, Y; Florjancic, AS; Garland, RB; Guo, Y; Heyman, HR; Stacey, JR; Steinman, DH; Albert, DH; Bouska, JJ; Elmore, IN; Goodfellow, CL; Marcotte, PA; Tapang, P; Morgan, DW; Michaelides, MR; Davidsen, SK Phenoxyphenyl sulfone N-formylhydroxylamines (retrohydroxamates) as potent, selective, orally bioavailable matrix metalloproteinase inhibitors. J Med Chem 45:219-32 (2001) [PubMed] Article
More Info.:
Target
Name:
Matrilysin
Synonyms:
MMP7 | MMP7_HUMAN | MPSL1 | Matrix metalloproteinase 7 | Matrix metalloproteinase-7 (MMP-7) | Matrix metalloproteinase-7 (MMP7) | PUMP1
Type:
Enzyme
Mol. Mass.:
29681.54
Organism:
Homo sapiens (Human)
Description:
P09237
Residue:
267
Sequence:
MRLTVLCAVCLLPGSLALPLPQEAGGMSELQWEQAQDYLKRFYLYDSETKNANSLEAKLKEMQKFFGLPITGMLNSRVIEIMQKPRCGVPDVAEYSLFPNSPKWTSKVVTYRIVSYTRDLPHITVDRLVSKALNMWGKEIPLHFRKVVWGTADIMIGFARGAHGDSYPFDGPGNTLAHAFAPGTGLGGDAHFDEDERWTDGSSLGINFLYAATHELGHSLGMGHSSDPNAVMYPTYGNGDPQNFKLSQDDIKGIQKLYGKRSNSRKK
Inhibitor
Name:
BDBM50063917
Synonyms:
(2S,3R)-N(4)-[(2S)-3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl]-N(1),2-dihydroxy-3-(2-methylpropyl)butanediamide | CHEMBL279785 | cid_119031 | marimastat
Type:
Small organic molecule
Emp. Form.:
C15H29N3O5
Mol. Mass.:
331.4079
SMILES:
CNC(=O)[C@@H](NC(=O)[C@H](CC(C)C)[C@H](O)C(=O)NO)C(C)(C)C |r|