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Target
Prostaglandin G/H synthase 1
Ligand
BDBM50066441
Substrate
n/a
Meas. Tech.
ChEMBL_159404 (CHEMBL763457)
IC50
<1±n/a nM
Citation
 Noguchi, T; Shimazawa, R; Nagasawa, K; Hashimoto, Y Thalidomide and its analogues as cyclooxygenase inhibitors. Bioorg Med Chem Lett 12:1043-6 (2002) [PubMed]  Article 
Target
Name:
Prostaglandin G/H synthase 1
Synonyms:
COX1 | Cyclooxygenase-1 | Cyclooxygenase-1 (COX-1) | PGH1_SHEEP | PTGS1 | Prostaglandin G/H synthase (cyclooxygenase)
Type:
Protein
Mol. Mass.:
68868.60
Organism:
Ovis aries (Sheep)
Description:
n/a
Residue:
600
Sequence:
MSRQSISLRFPLLLLLLSPSPVFSADPGAPAPVNPCCYYPCQHQGICVRFGLDRYQCDCTRTGYSGPNCTIPEIWTWLRTTLRPSPSFIHFLLTHGRWLWDFVNATFIRDTLMRLVLTVRSNLIPSPPTYNIAHDYISWESFSNVSYYTRILPSVPRDCPTPMDTKGKKQLPDAEFLSRRFLLRRKFIPDPQSTNLMFAFFAQHFTHQFFKTSGKMGPGFTKALGHGVDLGHIYGDNLERQYQLRLFKDGKLKYQMLNGEVYPPSVEEAPVLMHYPRGIPPQSQMAVGQEVFGLLPGLMLYATIWLREHNRVCDLLKAEHPTWGDEQLFQTARLILIGETIKIVIEEYVQQLSGYFLQLKFDPELLFGAQFQYRNRIAMEFNQLYHWHPLMPDSFRVGPQDYSYEQFLFNTSMLVDYGVEALVDAFSRQPAGRIGGGRNIDHHILHVAVDVIKESRVLRLQPFNEYRKRFGMKPYTSFQELTGEKEMAAELEELYGDIDALEFYPGLLLEKCHPNSIFGESMIEMGAPFSLKGLLGNPICSPEYWKASTFGGEVGFNLVKTATLKKLVCLNTKTCPYVSFHVPDPRQEDRPGVERPPTEL
  
Inhibitor
Name:
BDBM50066441
Synonyms:
2-(2,6-Dimethyl-phenyl)-isoindole-1,3-dione | 2-(2,6-dimethylphenyl)isoindoline-1,3-dione | CHEMBL8916
Type:
Small organic molecule
Emp. Form.:
C16H13NO2
Mol. Mass.:
251.2799
SMILES:
Cc1cccc(C)c1N1C(=O)c2ccccc2C1=O
Structure:
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