Target
Sorbitol dehydrogenase
Ligand
BDBM50113498
Substrate
n/a
Meas. Tech.
ChEBML_201005
IC50
19±n/a nM
Citation
 Chu-Moyer, MYBallinger, WEBeebe, DACoutcher, JBDay, WWLi, JOates, PJWeekly, RM SAR and species/stereo-selective metabolism of the sorbitol dehydrogenase inhibitor, CP-470,711. Bioorg Med Chem Lett 12:1477-80 (2002) [PubMed]  Article 
Target
Name:
Sorbitol dehydrogenase
Synonyms:
DHSO_HUMAN | L-iditol 2-dehydrogenase | SORD
Type:
PROTEIN
Mol. Mass.:
38332.20
Organism:
Homo sapiens (Human)
Description:
ChEMBL_223910
Residue:
357
Sequence:
MAAAAKPNNLSLVVHGPGDLRLENYPIPEPGPNEVLLRMHSVGICGSDVHYWEYGRIGNFIVKKPMVLGHEASGTVEKVGSSVKHLKPGDRVAIEPGAPRENDEFCKMGRYNLSPSIFFCATPPDDGNLCRFYKHNAAFCYKLPDNVTFEEGALIEPLSVGIHACRRGGVTLGHKVLVCGAGPIGMVTLLVAKAMGAAQVVVTDLSATRLSKAKEIGADLVLQISKESPQEIARKVEGQLGCKPEVTIECTGAEASIQAGIYATRSGGNLVLVGLGSEMTTVPLLHAAIREVDIKGVFRYCNTWPVAISMLASKSVNVKPLVTHRFPLEKALEAFETFKKGLGLKIMLKCDPSDQNP
  
Inhibitor
Name:
BDBM50113498
Synonyms:
(R)-1-(4-{(3S,5R)-4-[2-((S)-1-Hydroxy-ethyl)-pyrimidin-4-yl]-3,5-dimethyl-piperazin-1-yl}-pyrimidin-2-yl)-ethanol | CHEMBL34965
Type:
Small organic molecule
Emp. Form.:
C18H26N6O2
Mol. Mass.:
358.438
SMILES:
C[C@@H](O)c1nccc(n1)N1C[C@H](C)N([C@H](C)C1)c1ccnc(n1)[C@H](C)O
Structure:
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