Reaction Details Report a problem with these data
Target
Type-1 angiotensin II receptor
Ligand
BDBM50091105
Substrate
n/a
Meas. Tech.
ChEMBL_36920 (CHEMBL647120)
Ki
>0.000100±n/a nM
Citation
Murugesan, N; Tellew, JE; Gu, Z; Kunst, BL; Fadnis, L; Cornelius, LA; Baska, RA; Yang, Y; Beyer, SM; Monshizadegan, H; Dickinson, KE; Panchal, B; Valentine, MT; Chong, S; Morrison, RA; Carlson, KE; Powell, JR; Moreland, S; Barrish, JC; Kowala, MC; Macor, JE Discovery of N-isoxazolyl biphenylsulfonamides as potent dual angiotensin II and endothelin A receptor antagonists. J Med Chem 45:3829-35 (2002) [PubMed] Article
More Info.:
Target
Name:
Type-1 angiotensin II receptor
Synonyms:
AGTR1 | AGTR1A | AGTR1B | AGTR1_HUMAN | AT1 | AT1AR | AT1BR | AT2R1 | AT2R1B | Angiotensin II AT1 | Angiotensin II receptor | Angiotensin II type 1b (AT-1b) receptor | Type-1 angiotensin II receptor (AT1)
Type:
Protein
Mol. Mass.:
41080.75
Organism:
Homo sapiens (Human)
Description:
P30556
Residue:
359
Sequence:
MILNSSTEDGIKRIQDDCPKAGRHNYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLKTVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNYLCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLLAGLASLPAIIHRNVFFIENTNITVCAFHYESQNSTLPIGLGLTKNILGFLFPFLIILTSYTLIWKALKKAYEIQKNKPRNDDIFKIIMAIVLFFFFSWIPHQIFTFLDVLIQLGIIRDCRIADIVDTAMPITICIAYFNNCLNPLFYGFLGKKFKRYFLQLLKYIPPKAKSHSNLSTKMSTLSYRPSDNVSSSTKKPAPCFEVE
Inhibitor
Name:
BDBM50091105
Synonyms:
4''-Oxazol-2-yl-biphenyl-2-sulfonic acid (3,4-dimethyl-isoxazol-5-yl)-amide | 4'-Oxazol-2-yl-biphenyl-2-sulfonic acid (3,4-dimethyl-isoxazol-5-yl)-amide | 4'-Oxazol-2-yl-biphenyl-2-sulfonicacid(3,4-dimethyl-isoxazol-5-yl)-amide | BMS-193884 | CHEMBL24461
Type:
Small organic molecule
Emp. Form.:
C20H17N3O4S
Mol. Mass.:
395.432
SMILES:
Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(cc2)-c2ncco2)c1C