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Target
Translocator protein
Ligand
BDBM50118537
Substrate
n/a
Meas. Tech.
ChEMBL_37198 (CHEMBL650799)
Ki
0.18±n/a nM
Citation
 Campiani, G; Ramunno, A; Fiorini, I; Nacci, V; Morelli, E; Novellino, E; Goegan, M; Mennini, T; Sullivan, S; Zisterer, DM; Williams, CD Synthesis of new molecular probes for investigation of steroid biosynthesis induced by selective interaction with peripheral type benzodiazepine receptors (PBR). J Med Chem 45:4276-81 (2002) [PubMed]  Article 
Target
Name:
Translocator protein
Synonyms:
Benzodiazepine receptors; peripheral & central | Bzrp | Mbr | Mitochondrial benzodiazepine receptor | PBR | PKBS | Peripheral benzodiazepine receptor (PBR) | Peripheral-Type Benzodiazepine Receptor | TSPO_RAT | Tspo
Type:
Mitochondrion membrane protein
Mol. Mass.:
18945.84
Organism:
Rattus norvegicus (rat)
Description:
Competitive binding experiments were performed on rat kidney mitochondrial membranes.
Residue:
169
Sequence:
MSQSWVPAVGLTLVPSLGGFMGAYFVRGEGLRWYASLQKPSWHPPRWTLAPIWGTLYSAMGYGSYIIWKELGGFTEEAMVPLGLYTGQLALNWAWPPIFFGARQMGWALVDLMLVSGVATATTLAWHRVSPPAARLLYPYLAWLAFATMLNYYVWRDNSGRRGGSRLTE
  
Inhibitor
Name:
BDBM50118537
Synonyms:
CHEMBL135391 | Ethyl-carbamic acid 7-chloro-5-phenyl-6-oxa-10b-aza-benzo[e]azulen-4-yl ester
Type:
Small organic molecule
Emp. Form.:
C21H17ClN2O3
Mol. Mass.:
380.824
SMILES:
CCNC(=O)OC1=C(Oc2c(Cl)cccc2-n2cccc12)c1ccccc1 |t:6|
Structure:
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