Target
Sorbitol dehydrogenase
Ligand
BDBM50118711
Substrate
n/a
Meas. Tech.
ChEMBL_223914 (CHEMBL846060)
IC50
9.0±n/a nM
Citation
 Mylari, BLOates, PJZembrowski, WJBeebe, DAConn, ELCoutcher, JBO'Gorman, MTLinhares, MCWithbroe, GJ A sorbitol dehydrogenase inhibitor of exceptional in vivo potency with a long duration of action: 1-(R)-[4-[4-(4,6-dimethyl[1,3,5]triazin-2-yl)- 2R,6S-dimethylpiperazin-1-yl]pyrimidin-2- yl]ethanol. J Med Chem 45:4398-401 (2002) [PubMed]  Article 
Target
Name:
Sorbitol dehydrogenase
Synonyms:
DHSO_RAT | Sdh1 | Sord
Type:
PROTEIN
Mol. Mass.:
38239.67
Organism:
Rattus norvegicus
Description:
ChEMBL_223914
Residue:
357
Sequence:
MAAPAKGENLSLVVHGPGDIRLENYPIPELGPNDVLLKMHSVGICGSDVHYWEHGRIGDFVVKKPMVLGHEAAGTVTKVGPMVKHLKPGDRVAIEPGVPREIDEFCKIGRYNLTPSIFFCATPPDDGNLCRFYKHSADFCYKLPDSVTFEEGALIEPLSVGIYACRRGSVSLGNKVLVCGAGPIGIVTLLVAKAMGASQVVVIDLSASRLAKAKEVGADFTIQVAKETPHDIAKKVESVLGSKPEVTIECTGAESSVQTGIYATHSGGTLVVVGMGPEMINLPLVHAAVREVDIKGVFRYCNTWPMAVSMLASKTLNVKPLVTHRFPLEKAVEAFETAKKGLGLKVMIKCDPNDQNP
  
Inhibitor
Name:
BDBM50118711
Synonyms:
1-{4-[4-(4,6-Dimethyl-[1,3,5]triazin-2-yl)-2,6-dimethyl-piperazin-1-yl]-pyrimidin-2-yl}-ethanol | CHEMBL136680
Type:
Small organic molecule
Emp. Form.:
C17H25N7O
Mol. Mass.:
343.4267
SMILES:
C[C@@H](O)c1nccc(n1)N1[C@@H](C)CN(C[C@H]1C)c1nc(C)nc(C)n1
Structure:
Search PDB for entries with ligand similarity: