Reaction Details Report a problem with these data
Target
Translocator protein
Ligand
BDBM50007664
Substrate
n/a
Meas. Tech.
ChEBML_37065
Ki
438±n/a nM
Citation
 Pacofsky, GJ; Stafford, JA; Cox, RF; Cowan, JR; Dorsey, GF; Gonzales, SS; Kaldor, I; Koszalka, GW; Lovell, GG; McIntyre, MS; Tidwell, JH; Todd, D; Whitesell, G; Wiard, RP; Feldman, PL Relating the structure, activity, and physical properties of ultrashort-acting benzodiazepine receptor agonists. Bioorg Med Chem Lett 12:3219-22 (2002) [PubMed]  Article 
Target
Name:
Translocator protein
Synonyms:
Benzodiazepine receptors; peripheral & central | Bzrp | Mbr | Mitochondrial benzodiazepine receptor | PBR | PKBS | Peripheral benzodiazepine receptor (PBR) | Peripheral-Type Benzodiazepine Receptor | TSPO_RAT | Tspo
Type:
Mitochondrion membrane protein
Mol. Mass.:
18945.84
Organism:
Rattus norvegicus (rat)
Description:
Competitive binding experiments were performed on rat kidney mitochondrial membranes.
Residue:
169
Sequence:
MSQSWVPAVGLTLVPSLGGFMGAYFVRGEGLRWYASLQKPSWHPPRWTLAPIWGTLYSAMGYGSYIIWKELGGFTEEAMVPLGLYTGQLALNWAWPPIFFGARQMGWALVDLMLVSGVATATTLAWHRVSPPAARLLYPYLAWLAFATMLNYYVWRDNSGRRGGSRLTE
  
Inhibitor
Name:
BDBM50007664
Synonyms:
7-chloro-2-methylamino-5-phenyl-3H-1,4-benzodiazepin-4-oxide | 7-chloro-N-methyl-5-phenyl-3H-1,4-benzodiazepin-2-amine 4-oxide | CDP | CHEMBL451 | CHLORDIAZEPOXIDE | clopoxide | methaminodiazepoxide
Type:
Small organic molecule
Emp. Form.:
C16H14ClN3O
Mol. Mass.:
299.755
SMILES:
CNC1=Nc2ccc(Cl)cc2C(c2ccccc2)=[N+]([O-])C1 |t:2,19|
Structure:
Search PDB for entries with ligand similarity: