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Target
Growth hormone secretagogue receptor type 1
Ligand
BDBM50120505
Substrate
n/a
Meas. Tech.
ChEBML_89487
Ki
5±n/a nM
Citation
 Carpino, PA; Lefker, BA; Toler, SM; Pan, LC; Hadcock, JR; Murray, MC; Cook, ER; DiBrino, JN; DeNinno, SL; Chidsey-Frink, KL; Hada, WA; Inthavongsay, J; Lewis, SK; Mangano, FM; Mullins, MA; Nickerson, DF; Ng, O; Pirie, CM; Ragan, JA; Rose, CR; Tess, DA; Wright, AS; Yu, L; Zawistoski, MP; Pettersen, JC; DaSilva-Jardine, PA; Wilson, TC; Thompson, DD Discovery and biological characterization of capromorelin analogues with extended half-lives. Bioorg Med Chem Lett 12:3279-82 (2002) [PubMed]  Article 
Target
Name:
Growth hormone secretagogue receptor type 1
Synonyms:
GH-releasing peptide receptor | GHRP | GHS-R | GHSR | GHSR_HUMAN | Ghrelin Receptor (Growth Hormone Secretagogue Receptor Type 1) | Ghrelin receptor | Ghrelin receptor 1a (GHS-R1a)
Type:
Receptor
Mol. Mass.:
41334.57
Organism:
Homo sapiens (Human)
Description:
Receptor binding studies use plasma membranes from LLC PK-1 cells transiently transfected with hGHSR1a.
Residue:
366
Sequence:
MWNATPSEEPGFNLTLADLDWDASPGNDSLGDELLQLFPAPLLAGVTATCVALFVVGIAGNLLTMLVVSRFRELRTTTNLYLSSMAFSDLLIFLCMPLDLVRLWQYRPWNFGDLLCKLFQFVSESCTYATVLTITALSVERYFAICFPLRAKVVVTKGRVKLVIFVIWAVAFCSAGPIFVLVGVEHENGTDPWDTNECRPTEFAVRSGLLTVMVWVSSIFFFLPVFCLTVLYSLIGRKLWRRRRGDAVVGASLRDQNHKQTVKMLAVVVFAFILCWLPFHVGRYLFSKSFEPGSLEIAQISQYCNLVSFVLFYLSAAINPILYNIMSKKYRVAVFRLLGFEPFSQRKLSTLKDESSRAWTESSINT
  
Inhibitor
Name:
BDBM50120505
Synonyms:
2-Amino-N-{(R)-1-(2,4-difluoro-benzyloxymethyl)-2-oxo-2-[(R)-3-oxo-3a-pyridin-2-ylmethyl-2-(2,2,2-trifluoro-ethyl)-2,3,3a,4,6,7-hexahydro-pyrazolo[4,3-c]pyridin-5-yl]-ethyl}-2-methyl-propionamide | CHEMBL109980 | CP-464709-18
Type:
Small organic molecule
Emp. Form.:
C28H31F5N6O4
Mol. Mass.:
610.5756
SMILES:
CC(C)(N)C(=O)N[C@H](COCc1ccc(F)cc1F)C(=O)N1CCC2=NN(CC(F)(F)F)C(=O)[C@]2(Cc2ccccn2)C1 |t:25|
Structure:
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