Reaction Details Report a problem with these data
Target
Similar to alpha-tubulin isoform 1/Tubulin beta-2B chain
Ligand
BDBM50035218
Substrate
n/a
Meas. Tech.
ChEMBL_51441 (CHEMBL876699)
IC50
2100±n/a nM
Citation
 Mu, F; Hamel, E; Lee, DJ; Pryor, DE; Cushman, M Synthesis, anticancer activity, and inhibition of tubulin polymerization by conformationally restricted analogues of lavendustin A. J Med Chem 46:1670-82 (2003) [PubMed]  Article 
Target
Name:
Similar to alpha-tubulin isoform 1/Tubulin beta-2B chain
Synonyms:
Tubulin | Tubulin alpha chain /beta chain
Type:
n/a
Mol. Mass.:
n/a
Description:
ASSAY_ID of EBI is 51441
Components:
This complex has 2 components.
Component 1
Name:
Tubulin beta-2B chain
Synonyms:
TBB2B_BOVIN | TUBB2B | Tubulin | Tubulin beta chain
Type:
PROTEIN
Mol. Mass.:
49932.38
Organism:
Bos taurus
Description:
ChEMBL_211651
Residue:
445
Sequence:
MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDSDLQLERINVYYNEATGNKYVPRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKESESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVMPSPKVSDTVVEPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDSKNMMAACDPRHGRYLTVAAIFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRGLKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATADEQGEFEEEEGEDEA
  
Component 2
Name:
Similar to alpha-tubulin isoform 1
Synonyms:
Tubulin
Type:
PROTEIN
Mol. Mass.:
9422.48
Organism:
Bos taurus
Description:
EBI_18002
Residue:
84
Sequence:
PSPQVSTAVVEPYNSILTTKHLEHSDCFMVDNEAIYDICRRNLDIERPTTRNLNRLMSQIVSSITASLRFDGALTVDLTDVQTS
  
Inhibitor
Name:
BDBM50035218
Synonyms:
CHEMBL61 | PODOFILOX | Podophyllinic acid lactone | Podophyllotoxin (PTOX) | podophyllotoxin
Type:
Small organic molecule
Emp. Form.:
C22H22O8
Mol. Mass.:
414.4053
SMILES:
COc1cc(cc(OC)c1OC)[C@H]1[C@@H]2[C@H](COC2=O)[C@@H](O)c2cc3OCOc3cc12 |r|
Structure:
Search PDB for entries with ligand similarity: