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Target
Peptidyl-prolyl cis-trans isomerase FKBP1A
Ligand
BDBM50132550
Substrate
n/a
Meas. Tech.
ChEBML_66292
IC50
8.2±n/a nM
Citation
 Yang, W; Keenan, TP; Rozamus, LW; Wang, X; Rivera, VM; Rollins, CT; Clackson, T; Holt, DA Regulation of gene expression by synthetic dimerizers with novel specificity. Bioorg Med Chem Lett 13:3181-4 (2003) [PubMed]  Article 
Target
Name:
Peptidyl-prolyl cis-trans isomerase FKBP1A
Synonyms:
12 kDa FK506-binding protein | 12 kDa FKBP | FK506-binding protein 1A | FK506-binding protein 1A (FKBP12) | FKB1A_HUMAN | FKBP-12 | FKBP-1A | FKBP1 | FKBP12 | FKBP1A | Immunophilin FKBP12 | PPIase | PPIase FKBP1A | Peptidyl-prolyl cis-trans isomerase (FKBP) | Rotamase | RyR1/FKBP12 | mTOR/FKBP12A/FKBP12B
Type:
Isomerase
Mol. Mass.:
11953.09
Organism:
Homo sapiens (Human)
Description:
P62942
Residue:
108
Sequence:
MGVQVETISPGDGRTFPKRGQTCVVHYTGMLEDGKKFDSSRDRNKPFKFMLGKQEVIRGWEEGVAQMSVGQRAKLTISPDYAYGATGHPGIIPPHATLVFDVELLKLE
  
Inhibitor
Name:
BDBM50132550
Synonyms:
(S)-1-[(S)-2-(3,4,5-Trimethoxy-phenyl)-propionyl]-piperidine-2-carboxylic acid (R)-1-(3-carboxymethoxy-phenyl)-3-(3,4-dimethoxy-phenyl)-propyl ester | CHEMBL107101
Type:
Small organic molecule
Emp. Form.:
C37H45NO11
Mol. Mass.:
679.7533
SMILES:
COc1ccc(CC[C@@H](OC(=O)[C@@H]2CCCCN2C(=O)[C@@H](C)c2cc(OC)c(OC)c(OC)c2)c2cccc(OCC(O)=O)c2)cc1OC
Structure:
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