Target
Cruzipain
Ligand
BDBM50133622
Substrate
n/a
Meas. Tech.
ChEMBL_210992 (CHEMBL812106)
IC50
6000±n/a nM
Citation
 Chiyanzu, IHansell, EGut, JRosenthal, PJMcKerrow, JHChibale, K Synthesis and evaluation of isatins and thiosemicarbazone derivatives against cruzain, falcipain-2 and rhodesain. Bioorg Med Chem Lett 13:3527-30 (2003) [PubMed]  Article 
Target
Name:
Cruzipain
Synonyms:
CYSP_TRYCR | Cruzain | Cruzaine | Major cysteine proteinase
Type:
Protein
Mol. Mass.:
49831.41
Organism:
Trypanosoma cruzi
Description:
P25779
Residue:
467
Sequence:
MSGWARALLLAAVLVVMACLVPAATASLHAEETLTSQFAEFKQKHGRVYESAAEEAFRLSVFRENLFLARLHAAANPHATFGVTPFSDLTREEFRSRYHNGAAHFAAAQERARVPVKVEVVGAPAAVDWRARGAVTAVKDQGQCGSCWAFSAIGNVECQWFLAGHPLTNLSEQMLVSCDKTDSGCSGGLMNNAFEWIVQENNGAVYTEDSYPYASGEGISPPCTTSGHTVGATITGHVELPQDEAQIAAWLAVNGPVAVAVDASSWMTYTGGVMTSCVSEQLDHGVLLVGYNDSAAVPYWIIKNSWTTQWGEEGYIRIAKGSNQCLVKEEASSAVVGGPGPTPEPTTTTTTSAPGPSPSYFVQMSCTDAACIVGCENVTLPTGQCLLTTSGVSAIVTCGAETLTEEVFLTSTHCSGPSVRSSVPLNKCNRLLRGSVEFFCGSSSSGRLADVDRQRRHQPYHSRHRRL
  
Inhibitor
Name:
BDBM50133622
Synonyms:
5-Chloro-1-(4-chloro-benzyl)-1H-indole-2,3-dione | CHEMBL333067
Type:
Small organic molecule
Emp. Form.:
C15H9Cl2NO2
Mol. Mass.:
306.143
SMILES:
Clc1ccc(CN2C(=O)C(=O)c3cc(Cl)ccc23)cc1
Structure:
Search PDB for entries with ligand similarity: